Protein Alignment Sirt2 and sirt3

DIOPT Version :10

• Sequence 1: NP_650880.3
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: XP_009301762.1
• Gene: sirt3 / 558775
• ZFINID: ZDB-GENE-070112-1762
• Length: 358
• Species: Danio rerio
• Alignment Length: 306
• Identity: 151/306 - (49%)
• Similarity: 193/306 - (63%)
• Gaps: 24/306 - (7%)

  Fly    46 GGSSDAKEEVKVEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLK 110
            ||..|...:..:|.:         ||..|...|::||.|.||||||.:|||||||||||||.||:
Zfish    77 GGGRDNVHQQTLEDI---------AEKIRERKFKRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQ 132

  Fly   111 KYELPHPTAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLD 175
            :|.||:..|||:::||..||.||||||||||||::.|...|||||:|:||..|.|.||||||.|:
Zfish   133 QYNLPYAEAIFEINYFHHNPNPFFALAKELYPGNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLE 197

  Fly   176 RLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLP 240
            |:.|:|...::||||:|.|..|..||::|..:.::.:|.|..:|||..|:|::|||||||||.||
Zfish   198 RMAGIPPKMLVEAHGTFATATCTVCRRDYKGEELRDDIMAGTVPKCPTCKGIIKPDIVFFGEELP 262

  Fly   241 KRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRS 305
            :.|::. ..||...||||:|||||||:|||||.........|||||||.||.     |...:.|.
Zfish   263 QHFFTY-LTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGP-----FASGSQRH 321

  Fly   306 LLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITSERKKL 351
                     .|||.|||...||..|.:.|||.|||:.|:...|.|:
Zfish   322 ---------TDVAELGDVVNGVKKLVELLGWKQELEDLMNVGRDKV 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_650880.3	SIRT1	79..330	CDD:238699	133/250 (53%)
sirt3	XP_009301762.1	SIRT1	101..337	CDD:238699	133/250 (53%)