DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sirt2 and Sirt6

DIOPT Version :9

Sequence 1:NP_001287422.2 Gene:Sirt2 / 42414 FlyBaseID:FBgn0038788 Length:386 Species:Drosophila melanogaster
Sequence 2:NP_001365873.1 Gene:Sirt6 / 50721 MGIID:1354161 Length:334 Species:Mus musculus


Alignment Length:274 Identity:76/274 - (27%)
Similarity:116/274 - (42%) Gaps:60/274 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 IVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYPGSF 145
            :|...||||||::||||||.              ||  .::.::  |:..||.|....|    :.
Mouse    47 VVFHTGAGISTASGIPDFRG--------------PH--GVWTME--ERGLAPKFDTTFE----NA 89

  Fly   146 IPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMD--- 207
            .|:..|..:..|...|.|....:||:|.|...:|.|.||:.|.||:.....|.||:.:|..|   
Mouse    90 RPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVV 154

  Fly   208 ---WMKAEIFADRLPKCQK------CQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTS 263
               .:||   ..||....|      |:|.::..|:.:.::||.|.....:|..:..||.:.:|||
Mouse   155 GTMGLKA---TGRLCTVAKTRGLRACRGELRDTILDWEDSLPDRDLMLADEASRTADLSVTLGTS 216

  Fly   264 LEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVM 328
            |:::|..:|......|..||:|           :.:.|.       |.:...|:...|..|..:.
Mouse   217 LQIRPSGNLPLATKRRGGRLVI-----------VNLQPT-------KHDRQADLRIHGYVDEVMC 263

  Fly   329 ALAKALG-----WD 337
            .|.|.||     ||
Mouse   264 RLMKHLGLEIPAWD 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt2NP_001287422.2 SIRT1 79..330 CDD:238699 70/260 (27%)
Sirt6NP_001365873.1 SIRT7 45..257 CDD:238701 68/252 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..334
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54280
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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