DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sirt2 and Sirt2

DIOPT Version :9

Sequence 1:	NP_001287422.2	Gene:	Sirt2 / 42414	FlyBaseID:	FBgn0038788	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	XP_006228734.1	Gene:	Sirt2 / 361532	RGDID:	621481	Length:	489	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	188/456 - (41%)
Similarity:	245/456 - (53%)	Gaps:	101/456 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PSNSSSSDDDE---EAPDDTMDKVRRFFANTLHLGGSSDAKEEVKVEKVIPDLSFDGFAEHWRVH 76
            ||.:.|..|.|   ...:..||.:|..|..||.||...        |:::.:|:.:|...:.:..
  Rat    47 PSRTDSDSDTEGGATGGEAEMDFLRNLFTQTLGLGSQK--------ERLLDELTLEGVTRYMQSE 103

  Fly    77 GFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELY 141
            ..|:::.:|||||||||||||||||.:|||:||:||.||:|.|||::.||:|:|.||||||||||
  Rat   104 RCRRVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELY 168

  Fly   142 PGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCI--KCRKEY 204
            ||.|.||..|||||||.:||||.|.||||||||:|:.||....::||||:|:|:||:  .|.|||
  Rat   169 PGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCGKEY 233

  Fly   205 DMDWMKAEIFADRLPKCQKCQGVVKP--------------------------------------- 230
            .|.|||.:||::..|||:|||.||||
  Rat   234 TMSWMKEKIFSEATPKCEKCQNVVKPGEPQTPFFHWPARTSNLATLLPGLSPTVLQRVGICLPFP 298

  Fly   231 ---------------------------------DIVFFGENLPKRFYSSPEEDFQDCDLLIIMGT 262
                                             ||||||||||.||:|..:.||...||||||||
  Rat   299 PHPCPSWAPTPACFSSVPHVSSPLSLCLSVSTSDIVFFGENLPPRFFSCMQSDFSKVDLLIIMGT 363

  Fly   263 SLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLL-------FDKPNNTRDVAFL 320
            ||:|||||||:.:......|||||::..||.      ||....::       ||.....||||:|
  Rat   364 SLQVQPFASLISKAPLATPRLLINKEKTGQT------DPFLGMMMGLGGGMDFDSKKAYRDVAWL 422

  Fly   321 GDCDAGVMALAKALGWDQELQQLITSERKKL---SGSQNSEELQQGKEKPQSDPDKMTSGDRDKK 382
            ||||.|.:|||..|||.:||:.|:..|...:   ||||.|........:....|.|..:..::|:
  Rat   423 GDCDQGCLALADLLGWKKELEDLVRREHANIDAQSGSQASNPSATVSPRKSPPPAKEAARTKEKE 487

  Fly   383 D 383
            :
  Rat   488 E 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	154/331 (47%)
Sirt2	XP_006228734.1	SIRT1	106..432	CDD:238699	172/394 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338188
Domainoid	1	1.000	273	1.000	Domainoid score	I1724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40823
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2204
OMA	1	1.010	-	-		QHG54280
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		oto95918
orthoMCL	1	0.900	-	-		OOG6_101879
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1602
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910