Protein Alignment Sirt2 and Sirt1

DIOPT Version :10

• Sequence 1: NP_650880.3
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Alignment Length: 506
• Identity: 148/506 - (29%)
• Similarity: 221/506 - (43%)
• Gaps: 154/506 - (30%)

  Fly     2 GDIEVK----KEEQ------------PTTPSNSSSSDDDEEAPDDTMDK---------------- 34
            |:|:.|    :|||            ||........|::||..||..::
  Fly    72 GEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGITGTSNEDED 136

  Fly    35 ------------------VRRFFANTL----------H----LGGSSD-----------AKEEVK 56
                              .|.|:...:          |    |.|.:|           ..|..:
  Fly   137 SSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKR 201

  Fly    57 VEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKK--YELPHPTA 119
            ..|:....:||....  .|...:||:.:.|||:|.|.|||||||. :|:|:.|..  .:||.|.|
  Fly   202 RNKLASVNTFDDVIS--LVKKSQKIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQA 263

  Fly   120 IFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDK 184
            :||::||:::|.||:..|:|:|||.|.|:|.|.||::|..||.|.|:||||||||:|:.|:  .:
  Fly   264 MFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QR 326

  Fly   185 IIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQ------------------------ 225
            :||.||||.|..|.|||.:.:.|.::|:|||.|:|.|.:||
  Fly   327 VIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVEN 391

  Fly   226 GVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCI-----RLLI 285
            |::|||||||||.||..:::....|...|||||::|:||:|:|.|.:     |..|     ::||
  Fly   392 GIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHI-----PSSIPATVPQILI 451

  Fly   286 NRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALG-----WDQE-LQQLI 344
            ||:.:             ..|.|       ||..|||.|..:..:...|.     |.|. ..:.:
  Fly   452 NREQL-------------HHLKF-------DVELLGDSDVIINQICHRLSDNDDCWRQLCCDESV 496

  Fly   345 TSERKKLSGSQNSEE------------LQQGKEKPQSDPDKMTSGDRDKKD 383
            .:|.|:|...::|..            ..:.:.:.|.|.|..:.......|
  Fly   497 LTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSAD 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_650880.3	SIRT1	79..330	CDD:238699	113/281 (40%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	113/281 (40%)