Protein Alignment Sirt2 and hst4

DIOPT Version :10

• Sequence 1: NP_650880.3
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_593659.1
• Gene: hst4 / 2542366
• PomBaseID: SPAC1783.04C
• Length: 415
• Species: Schizosaccharomyces pombe
• Alignment Length: 362
• Identity: 105/362 - (29%)
• Similarity: 157/362 - (43%)
• Gaps: 93/362 - (25%)

  Fly    79 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLK-KYELP-HPTAIFDLDYFE--KNPAPFFALAKE 139
            ::||.:.|||||..|||||||| ..||:|:|: :|:|. ....:||...:.  |:...|.|:.::
pombe    58 KRIVVVTGAGISCDAGIPDFRS-SEGLFSSLRAEYKLNCSGKELFDGSVYRDLKSVNIFHAMIRK 121

  Fly   140 LY--PGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLD-RLTGL----------PEDKIIEAHGS 191
            |:  ..:..||..|.|:..|..:..|.|.||||||.|: ||.||          |....|..||:
pombe   122 LHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAPWPTTIPLHGT 186

  Fly   192 FHTNHCIKCR--KEYDMDWMKAEIFADR--LPKCQKC----------------QGVVKPDIVFFG 236
            .....|.:|.  |:::.|     || ||  :..|..|                :|.::|.||.:.
pombe   187 LEVVSCTRCSFLKKFNPD-----IF-DRNGVTVCPDCKTENEVRRIAGKRSVIEGCLRPRIVLYN 245

  Fly   237 ENLP--KRFYSSPEEDFQ---DCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCV 296
            |..|  :...|...:|.:   ||  ||:.|||.::         ||       :.|.....::||
pombe   246 EIHPDSESIGSVCSQDLKSRPDC--LIVAGTSCKI---------PG-------VKRIIKEMSNCV 292

  Fly   297 LFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMA-LAKALGWDQELQQLITSERKKLSGSQNSEEL 360
            .....|...|.:|:|  |:|  ||..||..|.. |..|:   :.|:.|:.:...||    .|...
pombe   293 HKQKGNVIWLNYDEP--TKD--FLNLCDLVVQGDLQIAI---RRLKPLLDAPSWKL----KSHSA 346

  Fly   361 QQGKEKPQSDPDKMT--------------SGDRDKKD 383
            ::..::..|:..|:|              |.|..|||
pombe   347 KRTSKQKSSEQTKITSSTKITKAIGLNTKSNDSSKKD 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_650880.3	SIRT1	79..330	CDD:238699	90/293 (31%)
hst4	NP_593659.1	SIR2-fam	58..322	CDD:238698	90/292 (31%)