DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sirt2 and hst4

DIOPT Version :9

Sequence 1:	NP_001287422.2	Gene:	Sirt2 / 42414	FlyBaseID:	FBgn0038788	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_593659.1	Gene:	hst4 / 2542366	PomBaseID:	SPAC1783.04c	Length:	415	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	105/362 - (29%)
Similarity:	157/362 - (43%)	Gaps:	93/362 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLK-KYELP-HPTAIFDLDYFE--KNPAPFFALAKE 139
            ::||.:.|||||..|||||||| ..||:|:|: :|:|. ....:||...:.  |:...|.|:.::
pombe    58 KRIVVVTGAGISCDAGIPDFRS-SEGLFSSLRAEYKLNCSGKELFDGSVYRDLKSVNIFHAMIRK 121

  Fly   140 LY--PGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLD-RLTGL----------PEDKIIEAHGS 191
            |:  ..:..||..|.|:..|..:..|.|.||||||.|: ||.||          |....|..||:
pombe   122 LHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAPWPTTIPLHGT 186

  Fly   192 FHTNHCIKCR--KEYDMDWMKAEIFADR--LPKCQKC----------------QGVVKPDIVFFG 236
            .....|.:|.  |:::.|     || ||  :..|..|                :|.::|.||.:.
pombe   187 LEVVSCTRCSFLKKFNPD-----IF-DRNGVTVCPDCKTENEVRRIAGKRSVIEGCLRPRIVLYN 245

  Fly   237 ENLP--KRFYSSPEEDFQ---DCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCV 296
            |..|  :...|...:|.:   ||  ||:.|||.::         ||       :.|.....::||
pombe   246 EIHPDSESIGSVCSQDLKSRPDC--LIVAGTSCKI---------PG-------VKRIIKEMSNCV 292

  Fly   297 LFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMA-LAKALGWDQELQQLITSERKKLSGSQNSEEL 360
            .....|...|.:|:|  |:|  ||..||..|.. |..|:   :.|:.|:.:...||    .|...
pombe   293 HKQKGNVIWLNYDEP--TKD--FLNLCDLVVQGDLQIAI---RRLKPLLDAPSWKL----KSHSA 346

  Fly   361 QQGKEKPQSDPDKMT--------------SGDRDKKD 383
            ::..::..|:..|:|              |.|..|||
pombe   347 KRTSKQKSSEQTKITSSTKITKAIGLNTKSNDSSKKD 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	90/293 (31%)
hst4	NP_593659.1	SIR2	50..339	CDD:223915	94/312 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910