DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt2 and SIRT1

DIOPT Version :9

Sequence 1:	NP_001287422.2	Gene:	Sirt2 / 42414	FlyBaseID:	FBgn0038788	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_036370.2	Gene:	SIRT1 / 23411	HGNCID:	14929	Length:	747	Species:	Homo sapiens

Alignment Length:	301	Identity:	117/301 - (38%)
Similarity:	172/301 - (57%)	Gaps:	52/301 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKK--YELPHPTAIFDLDYFEKNPAPFFALAKELY 141
            :||:.:.|||:|.|.||||||| ..|:|:.|..  .:||.|.|:||::||.|:|.|||..|||:|
Human   254 KKIIVLTGAGVSVSCGIPDFRS-RDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIY 317

  Fly   142 PGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDM 206
            ||.|.|:..|.||.|.:.:|.|.|:||||||||:::.|:  .:||:.||||.|..|:.|:.:.|.
Human   318 PGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGI--QRIIQCHGSFATASCLICKYKVDC 380

  Fly   207 DWMKAEIFADRLPKCQKCQ-----GVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEV 266
            :.::.:||...:|:|.:|.     .::||:|||||||||::|:.:.:.|..:.||||::|:||:|
Human   381 EAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKV 445

  Fly   267 QPFASLVWRPGPRCI-----RLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAG 326
            :|.|.:     |..|     ::||||:.:                    |:...||..|||||..
Human   446 RPVALI-----PSSIPHEVPQILINREPL--------------------PHLHFDVELLGDCDVI 485

  Fly   327 VMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKP 367
            :..|...||          .|..||  ..|..:|.:..|||
Human   486 INELCHRLG----------GEYAKL--CCNPVKLSEITEKP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	106/262 (40%)
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135
		Interaction with H1-4. /evidence=ECO:0000269\|PubMed:15469825	2..268		6/13 (46%)
		Interaction with CLOCK. /evidence=ECO:0000250\|UniProtKB:Q923E4	2..139
		Nuclear localization signal. /evidence=ECO:0000250	32..39
		Nuclear export signal. /evidence=ECO:0000250	138..145
		Interaction with CCAR2	143..541		117/301 (39%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230
		SIRT1	254..489	CDD:238699	106/262 (40%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269\|PubMed:25406032	256..259		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..549
		Phosphorylated at one of three serine residues	538..540
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950