Protein Alignment Sirt2 and SIRT3

DIOPT Version :10

• Sequence 1: NP_650880.3
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_001357239.1
• Gene: SIRT3 / 23410
• HGNCID: 14931
• Length: 417
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 163/337 - (48%)
• Similarity: 212/337 - (62%)
• Gaps: 34/337 - (10%)

  Fly    46 GGSSDAKEEVKVEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLK 110
            |||||..:          ||....||..|....:::|.||||||||.:||||||||||||||||:
Human   115 GGSSDKGK----------LSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQ 169

  Fly   111 KYELPHPTAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLD 175
            :|:||:|.|||:|.:|..||.|||.||||||||::.|...|||:|||:|||||.|.||||||.|:
Human   170 QYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLE 234

  Fly   176 RLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLP 240
            |::|:|..|::||||:|.:..|..|::.:..:.::|::.|||:|:|..|.||||||||||||.||
Human   235 RVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLP 299

  Fly   241 KRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRS 305
            :||... ..||...|||:|:||||||:|||||.........|||||||.||.    |...|
Human   300 QRFLLH-VVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGP----LAWHP---- 355

  Fly   306 LLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKPQSD 370
                   .:||||.|||...||.:|.:.|||.:|::.|:..|..|:   |.:||     :.|:..
Human   356 -------RSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKV---QTAEE-----DHPRGC 405

  Fly   371 PDKMTSGDRDKK 382
            |...:..|...|
Human   406 PSHCSRLDGPDK 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_650880.3	SIRT1	79..330	CDD:238699	138/250 (55%)
SIRT3	NP_001357239.1	SIRT1	138..373	CDD:238699	138/250 (55%)