Protein Alignment Sirt2 and SIRT4

DIOPT Version :9

• Sequence 1: NP_001287422.2
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_001372662.1
• Gene: SIRT4 / 23409
• HGNCID: 14932
• Length: 314
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 64/265 - (24%)
• Similarity: 111/265 - (41%)
• Gaps: 79/265 - (29%)

  Fly    79 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYPG 143
            ::::.|.||||||.:||||:||...|||:...:..:.|.      |:....|     :.:..:..
Human    55 KRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHG------DFVRSAP-----IRQRYWAR 108

  Fly   144 SFI---------PTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIK 199
            :|:         |.|||:.:......|.|....|||:|.|....|  ..::.|.||......|:.
Human   109 NFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAG--SRRLTELHGCMDRVLCLD 171

  Fly   200 CRKEY---------------------------DMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGE 237
            |.::.                           |:...:.::.:.::|.|.:|.|.:|||:||||:
Human   172 CGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGD 236

  Fly   238 NLPKRFYSSPEE-DF-----QDCDLLIIMGTSLEVQP---FASLVWRP---------GP------ 278
            .:      :|:: ||     ::.|.|:::|:||:|..   |....|..         ||
Human   237 TV------NPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDL 295

  Fly   279 RCIRL 283
            .|::|
Human   296 ACLKL 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	64/265 (24%)
SIRT4	NP_001372662.1	SIRT4	47..308	CDD:238700	64/265 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910