Protein Alignment Sirt2 and sir-2.1

DIOPT Version :9

• Sequence 1: NP_001287422.2
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_001255484.1
• Gene: sir-2.1 / 177924
• WormBaseID: WBGene00004800
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 429
• Identity: 135/429 - (31%)
• Similarity: 215/429 - (50%)
• Gaps: 102/429 - (23%)

  Fly     2 GDIEVKKEEQP--------------------------TTPSNSSSSDDDEEAPDDTMDKVRR--- 37
            |:::...||.|                          .|.|.:|.|.:..:..|:.|..:||
 Worm    16 GEVQEITEENPEIGSMHITQETDISDAPETNTDSSRQRTESTTSVSSESWQNNDEMMSNLRRAQR 80

  Fly    38 ------------------FFANTL-------HLGGSSDAKEEVKVEKVIPDLSFDGFAEHWRVHG 77
                              |.|:.:       |....||..|...|.:.:  .:::..|:...:..
 Worm    81 LLDDGATPLQIIQQIFPDFNASRIATMSENAHFAILSDLLERAPVRQKL--TNYNSLADAVELFK 143

  Fly    78 FRK-IVTMVGAGISTSAGIPDFRSPGSGLYSNLKKY--ELPHPTAIFDLDYFEKNPAPFFALAKE 139
            .:| |:.:.|||:|.|.|||||||. .|:|:.|:..  :||.|||:||:.||.:|||||:..|:|
 Worm   144 TKKHILVLTGAGVSVSCGIPDFRSK-DGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFARE 207

  Fly   140 LYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEY 204
            ::||.|:|:.:|.||:.|...|.|.|:||||||||:..||:  .:::|.||||....|.:|.::|
 Worm   208 IFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGI--KRVVECHGSFSKCTCTRCGQKY 270

  Fly   205 DMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPF 269
            |.:.::.|:.|.|:..|::|:||:||:||||||:|.:.|:....||....||::::|:||:|:|.
 Worm   271 DGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPV 335

  Fly   270 ASLVWRPGPRCI-----RLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMA 329
            |.:     |.|:     ::||||:::                    |:...|:..||:||..:..
 Worm   336 ALI-----PHCVDKNVPQILINRESL--------------------PHYNADIELLGNCDDIIRD 375

  Fly   330 LAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKPQ 368
            :..:||  ....:|||        |.:|...||||.|.|
 Worm   376 ICFSLG--GSFTELIT--------SYDSIMEQQGKTKSQ 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	102/258 (40%)
sir-2.1	NP_001255484.1	SIRT1	146..376	CDD:238699	102/257 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950