DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt2 and sirt1

DIOPT Version :9

Sequence 1:	NP_001287422.2	Gene:	Sirt2 / 42414	FlyBaseID:	FBgn0038788	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	XP_012821550.2	Gene:	sirt1 / 100145679	XenbaseID:	XB-GENE-989003	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	319	Identity:	120/319 - (37%)
Similarity:	182/319 - (57%)	Gaps:	59/319 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKK--YELPHPTAIFDLDYFEKNPAPFFALAKELY 141
            :||:.:.|||:|.|.||||||| ..|:|:.|..  .:||:|.|:||::||.|:|.|||..|||::
Frog   294 KKIIVLTGAGVSVSCGIPDFRS-RDGIYARLAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIF 357

  Fly   142 PGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDM 206
            ||.|.|:..|.||.:|:.:..|.|:||||||||:::.|:  :|||:.||||....|:.|:.:.|.
Frog   358 PGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGI--EKIIQCHGSFAEASCLVCKYKVDC 420

  Fly   207 DWMKAEIFADRLPKCQKCQ-----GVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEV 266
            :.::.:||...:|:|.:|.     .::||||||||||||::|:.:.:.|..:.||||::|:||:|
Frog   421 EAVREDIFNQIVPRCPRCSSDEPLAIMKPDIVFFGENLPEQFHRAMKYDKNEVDLLIVIGSSLKV 485

  Fly   267 QPFASLVWRPGPRCI-----RLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAG 326
            :|.|.:     |..|     ::||||:.:                    |:...|:..|||||..
Frog   486 RPVALI-----PSSIPHEVPQILINREPL--------------------PHLHFDIELLGDCDVI 525

  Fly   327 VMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKPQ-------SDPDKMTSGD 378
            :..|.:.|  |.:..||.|          ||.:|.|..|||.       :.|:.:.|.|
Frog   526 INELCQRL--DGKYSQLCT----------NSLKLSQITEKPPRIHKGFLTSPETVPSTD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	104/262 (40%)
sirt1	XP_012821550.2	SIRT1	294..529	CDD:238699	104/262 (40%)
sirt1	XP_012821550.2	MSCRAMM_ClfB	<593..753	CDD:411414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950