DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and ZNF93

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_112495.2	Gene:	ZNF93 / 81931	HGNCID:	13169	Length:	620	Species:	Homo sapiens

Alignment Length:	479	Identity:	150/479 - (31%)
Similarity:	200/479 - (41%)	Gaps:	122/479 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HTPISPMKQE-------VQSVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYK 171
            ||...|.|.:       ..|.:|:.| ::...:|..:|..|...|.|.:||..|.||||.|:|||
Human   223 HTGEKPYKCDKCDKAFIASSTLSKHE-IIHTGKKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYK 286

  Fly   172 CKHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTH---------KAAESST 227
            |:.|.|||.|.||||.|.||||||||:.|..|.|.|:....|..|.:.|         |..::..
Human   287 CEECGKAFNQSSTLTKHKKIHTGEKPYVCEECGKAFKYSRILTTHKRIHTGEKPYKCNKCGKAFI 351

  Fly   228 PTSLLNYQPQTGSG-KHRKSQ------MHQAYQQQHQRVQISKTLY-------SGSYSSPAAEEL 278
            .:|.|:.......| ||.|.:      :..:...:|:||...:..|       :..|||..:...
Human   352 ASSTLSRHEFIHMGKKHYKCEECGKAFIWSSVLTRHKRVHTGEKPYKCEECGKAFKYSSTLSSHK 416

  Fly   279 -----VKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPY 338
                 .||::|..|.:.|...|||..||..|...||||||.|.|:|:|.::|..|||||||:|||
Human   417 RSHTGEKPYKCEECGKAFVASSTLSKHEIIHTGKKPYKCEECGKAFNQSSSLTKHKKIHTGEKPY 481

  Fly   339 TCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLL 403
            .|..|...|.|.|:||.|.|.||                                       |..
Human   482 KCEECGKAFNQSSSLTKHKKIHT---------------------------------------GEK 507

  Fly   404 PNNLH--GSTANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINM 466
            |....  |...|                          .::|.::|
Human   508 PYKCEECGKAFN--------------------------QSSTLIKH------------------- 527

  Fly   467 LKGDNPDRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKP 531
            .|....::|:.|..|.:.|...:.|..|...|||||||:|:.|...|...|||::|.|||:||||
Human   528 KKIHTREKPYKCEECGKAFHLSTHLTTHKILHTGEKPYRCRECGKAFNHSATLSSHKKIHSGEKP 592

  Fly   532 YNCSFCPKQFRQKSTLQNHLRVHT 555
            |.|..|.|.|...|:|..|..:||
Human   593 YECDKCGKAFISPSSLSRHEIIHT 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	8/19 (42%)
		zf-H2C2_2	157..181	CDD:290200	15/23 (65%)
		C2H2 Zn finger	172..192	CDD:275368	12/19 (63%)
		zf-H2C2_2	185..209	CDD:290200	15/23 (65%)
		C2H2 Zn finger	200..220	CDD:275368	6/19 (32%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-C2H2_8	287..363	CDD:292531	40/75 (53%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	506..526	CDD:275368	8/19 (42%)
		zf-H2C2_2	519..543	CDD:290200	14/23 (61%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		COG5048	170..612	CDD:227381	147/473 (31%)
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368	150/479 (31%)
		zf-H2C2_2	215..238	CDD:290200	4/14 (29%)
		C2H2 Zn finger	231..251	CDD:275368	3/20 (15%)
		zf-H2C2_2	244..268	CDD:290200	6/24 (25%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		zf-H2C2_2	272..296	CDD:290200	15/23 (65%)
		C2H2 Zn finger	287..307	CDD:275368	12/19 (63%)
		zf-H2C2_2	300..324	CDD:290200	15/23 (65%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..350	CDD:290200	4/21 (19%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	2/19 (11%)
		zf-H2C2_2	384..408	CDD:290200	4/23 (17%)
		C2H2 Zn finger	399..419	CDD:275368	3/19 (16%)
		zf-H2C2_2	412..435	CDD:290200	4/22 (18%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		zf-H2C2_2	440..464	CDD:290200	13/23 (57%)
		C2H2 Zn finger	455..475	CDD:275368	10/19 (53%)
		zf-H2C2_2	467..492	CDD:290200	14/24 (58%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		zf-H2C2_2	495..520	CDD:290200	10/89 (11%)
		C2H2 Zn finger	511..531	CDD:275368	5/64 (8%)
		zf-H2C2_2	524..547	CDD:290200	5/41 (12%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		zf-H2C2_2	551..576	CDD:290200	12/24 (50%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		zf-H2C2_2	580..602	CDD:290200	13/21 (62%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010