DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and znf1004

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001107936.1	Gene:	znf1004 / 799653	ZFINID:	ZDB-GENE-080219-20	Length:	934	Species:	Danio rerio

Alignment Length:	494	Identity:	152/494 - (30%)
Similarity:	203/494 - (41%)	Gaps:	152/494 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HTPISPMK--------QEVQSVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPY 170
            ||...|.|        ..::|..|.|  ::....|..:|..|..:|.||...:.|.:|||.|:||
Zfish   504 HTGEKPYKCSHCDKRFNRLESQKSHE--MIHTGEKSYKCSHCDKRFSQLQNQKIHERIHTGEKPY 566

  Fly   171 KCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHI------KTHKA------- 222
            ||.||.|.|.|:..:..|.:|||||||:||..|.|.:.:.::|.||:      ||||.
Zfish   567 KCLHCGKRFSQLGNMKLHERIHTGEKPYTCTQCGKSYGRSASLNNHMLIHTGKKTHKCDQCGKSF 631

  Fly   223 -AESSTPTSL---LNYQPQ--TGSGKHRKSQMHQAYQQQHQRVQIS------------------- 262
             |.:...|.|   .|.:|.  ...|| |.:|  :||..:||:....
Zfish   632 LAATRLKTHLRFHTNEKPYLCPVCGK-RFAQ--KAYLSEHQKTHTGVKEYMCFECDKTFLRAHQL 693

  Fly   263 ---KTLYSGSYSSPAAEELVKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLAT 324
               :|:::|.          ||::||.|.:||.:|.....|||.|...|||||..|.|.||.||.
Zfish   694 KWHQTIHTGE----------KPYKCSHCDKRFNRLERQTTHERIHTGEKPYKCSHCGKRFSMLAH 748

  Fly   325 LANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPA 389
            |..|:.||||:|||||:.|...|.|.|.|..|::.||               |..|...|..
Zfish   749 LKTHETIHTGEKPYTCTRCGKSFAQSSNLYRHMRIHT---------------GVKTHKCDQC--- 795

  Fly   390 PLAPGTQQLTSGLLPNNLHG---STANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVEHFQAG 451
                               |   |||:.:::.
Zfish   796 -------------------GKTFSTASCLKIH--------------------------------- 808

  Fly   452 GSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQV 516
                           |:....::|:.|:||.:.||.||:|..|.|.|||.|.|.|..||..|...
Zfish   809 ---------------LRSHTKEKPYSCTVCGKSFSTQSSLRLHQKIHTGLKEYMCFECEKTFISA 858

  Fly   517 ATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVHT 555
            |.|..|..||||||||.||.|.|:|.:...|..|.|:||
Zfish   859 AKLKRHQMIHTGEKPYKCSHCNKRFSELGNLTTHERIHT 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		zf-H2C2_2	157..181	CDD:290200	13/23 (57%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		zf-H2C2_2	185..209	CDD:290200	12/23 (52%)
		C2H2 Zn finger	200..220	CDD:275368	7/25 (28%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-C2H2_8	287..363	CDD:292531	38/75 (51%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	10/19 (53%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	519..543	CDD:290200	15/23 (65%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
znf1004	NP_001107936.1	C2H2 Zn finger	64..84	CDD:275368
		zf-H2C2_2	76..101	CDD:290200
		COG5048	88..502	CDD:227381
		C2H2 Zn finger	92..112	CDD:275368
		C2H2 Zn finger	120..140	CDD:275368
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		C2H2 Zn finger	204..224	CDD:275368
		zf-H2C2_2	216..241	CDD:290200
		C2H2 Zn finger	232..252	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		C2H2 Zn finger	316..336	CDD:275368
		C2H2 Zn finger	344..364	CDD:275368
		C2H2 Zn finger	372..392	CDD:275368
		zf-H2C2_2	384..409	CDD:290200
		C2H2 Zn finger	400..420	CDD:275368
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368
		COG5048	480..864	CDD:227381	133/459 (29%)
		C2H2 Zn finger	484..504	CDD:275368	152/494 (31%)
		zf-H2C2_2	497..521	CDD:290200	4/16 (25%)
		C2H2 Zn finger	512..532	CDD:275368	3/21 (14%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
		C2H2 Zn finger	596..616	CDD:275368	6/19 (32%)
		C2H2 Zn finger	624..644	CDD:275368	3/19 (16%)
		C2H2 Zn finger	652..672	CDD:275368	8/22 (36%)
		C2H2 Zn finger	680..700	CDD:275368	1/19 (5%)
		C2H2 Zn finger	708..728	CDD:275368	9/19 (47%)
		C2H2 Zn finger	736..756	CDD:275368	9/19 (47%)
		C2H2 Zn finger	764..784	CDD:275368	7/19 (37%)
		zf-H2C2_2	776..801	CDD:290200	8/61 (13%)
		C2H2 Zn finger	792..812	CDD:275368	6/89 (7%)
		C2H2 Zn finger	820..840	CDD:275368	10/19 (53%)
		C2H2 Zn finger	848..868	CDD:275368	7/19 (37%)
		C2H2 Zn finger	876..896	CDD:275368	8/19 (42%)
		zf-H2C2_2	888..913	CDD:290200	5/10 (50%)
		C2H2 Zn finger	904..924	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000