DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4360 and ZNF84

DIOPT Version :9

Sequence 1:NP_650879.1 Gene:CG4360 / 42413 FlyBaseID:FBgn0038787 Length:556 Species:Drosophila melanogaster
Sequence 2:NP_001120844.1 Gene:ZNF84 / 7637 HGNCID:13159 Length:738 Species:Homo sapiens


Alignment Length:526 Identity:164/526 - (31%)
Similarity:238/526 - (45%) Gaps:75/526 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 QHPLVHLLDISTTTANSGG---------GGGGSHTPISPMK-QEVQSVISEEEVVVDDPR----- 139
            :|...|:.||:....|.|.         ....:||...|.. .:.....|::..:....|     
Human   224 KHQSRHIRDIAFGCGNCGKTFPQKSQFITHHRTHTGEKPYNCSQCGKAFSQKSQLTSHQRTHTGE 288

  Fly   140 KKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICA 204
            |..:|..|...|.:.:.|.:|.:.||.|:||.|..|.:||.:.|.|.||.:||||||||.|..|.
Human   289 KPYECGECGKAFSRKSHLISHWRTHTGEKPYGCNECGRAFSEKSNLINHQRIHTGEKPFECRECG 353

  Fly   205 KDFRQQSTLINHIKTHKAAES----------STPTSLLNYQP-QTGSGKHRKSQMHQAYQQQ--- 255
            |.|.::|.|:.|.:||...:.          ...:.|:.:|. .||...:..|:..:|::::   
Human   354 KAFSRKSQLVTHHRTHTGTKPFGCSDCRKAFFEKSELIRHQTIHTGEKPYECSECRKAFRERSSL 418

  Fly   256 --HQR----------VQISKTLYSGSY--SSPAAEELVKPFQCSVCKRRFPQLSTLHNHERTHID 306
              |||          :|..|.....|:  |........|||.||.|.:.|.:.|.|..|:|||..
Human   419 INHQRTHTGEKPHGCIQCGKAFSQKSHLISHQMTHTGEKPFICSKCGKAFSRKSQLVRHQRTHTG 483

  Fly   307 PKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGG 371
            .|||:|..|.|:||:..:|.||::||||:|||.||.|...|.|:|.|.:|.:|||.: .|.....
Human   484 EKPYECSECGKAFSEKLSLTNHQRIHTGEKPYVCSECGKAFCQKSHLISHQRTHTGE-KPYECSE 547

  Fly   372 AGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLP---NNLHGSTANIIQLDHHPLLH--------- 424
            .|...|..::...|          |:..:|..|   .:...:.:...||:.|..:|         
Human   548 CGKAFGEKSSLATH----------QRTHTGEKPYECRDCEKAFSQKSQLNTHQRIHTGEKPYECS 602

  Fly   425 -----FLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRF 484
                 |.:    .|.::.....:|..:.::..............||..:....::||.||.|.:.
Human   603 LCRKAFFE----KSELIRHLRTHTGEKPYECNECRKAFREKSSLINHQRIHTGEKPFECSECGKA 663

  Fly   485 FSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQN 549
            ||::|.|:.|.:||||||||.|..|...|.|.:.|.||.:||||||||.|..|.|.|.|||.|.|
Human   664 FSRKSHLIPHQRTHTGEKPYGCSECRKAFSQKSQLVNHQRIHTGEKPYRCIECGKAFSQKSQLIN 728

  Fly   550 HLRVHT 555
            |.|.||
Human   729 HQRTHT 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4360NP_650879.1 C2H2 Zn finger 144..164 CDD:275368 5/19 (26%)
zf-H2C2_2 157..181 CDD:290200 11/23 (48%)
C2H2 Zn finger 172..192 CDD:275368 8/19 (42%)
zf-H2C2_2 185..209 CDD:290200 15/23 (65%)
C2H2 Zn finger 200..220 CDD:275368 7/19 (37%)
C2H2 Zn finger 284..304 CDD:275368 8/19 (42%)
zf-C2H2_8 287..363 CDD:292531 37/75 (49%)
C2H2 Zn finger 312..332 CDD:275368 8/19 (42%)
C2H2 Zn finger 340..360 CDD:275368 8/19 (42%)
C2H2 Zn finger 478..498 CDD:275368 8/19 (42%)
zf-H2C2_2 491..515 CDD:290200 13/23 (57%)
C2H2 Zn finger 506..526 CDD:275368 7/19 (37%)
zf-H2C2_2 519..543 CDD:290200 15/23 (65%)
C2H2 Zn finger 534..554 CDD:275368 11/19 (58%)
ZNF84NP_001120844.1 KRAB 9..68 CDD:214630
C2H2 Zn finger 209..229 CDD:275368 1/4 (25%)
C2H2 Zn finger 237..257 CDD:275368 2/19 (11%)
C2H2 Zn finger 265..285 CDD:275368 2/19 (11%)
zf-H2C2_2 278..302 CDD:316026 5/23 (22%)
C2H2 Zn finger 293..313 CDD:275368 5/19 (26%)
COG5048 317..724 CDD:227381 136/421 (32%)
C2H2 Zn finger 321..341 CDD:275368 8/19 (42%)
C2H2 Zn finger 349..369 CDD:275368 7/19 (37%)
C2H2 Zn finger 377..397 CDD:275368 2/19 (11%)
C2H2 Zn finger 405..425 CDD:275368 5/19 (26%)
C2H2 Zn finger 433..453 CDD:275368 4/19 (21%)
C2H2 Zn finger 461..481 CDD:275368 8/19 (42%)
C2H2 Zn finger 489..509 CDD:275368 8/19 (42%)
C2H2 Zn finger 517..537 CDD:275368 8/19 (42%)
C2H2 Zn finger 545..565 CDD:275368 4/29 (14%)
C2H2 Zn finger 573..593 CDD:275368 3/19 (16%)
C2H2 Zn finger 601..621 CDD:275368 2/23 (9%)
C2H2 Zn finger 629..649 CDD:275368 2/19 (11%)
C2H2 Zn finger 657..677 CDD:275368 8/19 (42%)
C2H2 Zn finger 685..705 CDD:275368 7/19 (37%)
C2H2 Zn finger 713..733 CDD:275368 11/19 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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