DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and Zfp429

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001074410.1	Gene:	Zfp429 / 72807	MGIID:	1920057	Length:	485	Species:	Mus musculus

Alignment Length:	438	Identity:	125/438 - (28%)
Similarity:	174/438 - (39%)	Gaps:	121/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 DDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTC 200
            |.|.|.|:||   ..|...::|..|||.||||:.|||:.|.:.|..:|.|..|.:||:||||:.|
Mouse   144 DKPYKCKECH---KAFSTRSSLFIHMKNHTDEKIYKCEDCGRTFYYLSMLKQHQRIHSGEKPYKC 205

  Fly   201 NICAKDFRQQSTLINHIKTHKAAESSTPTSLLNYQPQTGSGKHRKSQMHQAYQ------------ 253
            ..|.|.|...|.|..|.:.|                      .||:    ||.
Mouse   206 EECGKCFGFPSFLKQHQRLH----------------------CRKN----AYMYEECVKRFPPPL 244

  Fly   254 --QQHQRVQISKTLYSGSYSSPAAEELVKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCD 316
              |:|::::              .||  ||::|....:.|...|.|..|:..|...:|||||.|.
Mouse   245 PLQEHEQIR--------------TEE--KPYKCGERYKTFRYHSALRIHKAVHTGERPYKCEECG 293

  Fly   317 KSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTA 381
            |.||..:.|..|:.:|:.|.||.|..|:..||..|.|..|...||.: .|......|
Mouse   294 KCFSSSSCLKKHQILHSEDNPYKCEECYKAFRNHSALRIHKTVHTGE-RPYKCKDCG-------- 349

  Fly   382 TVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVE 446
                                    ..:.|::   .|..|.:||                  :|..
Mouse   350 ------------------------KCYSSSS---CLKRHQILH------------------SKYN 369

  Fly   447 HFQAGGSPSGRMTVVGTINMLKGDNP----DRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCK 507
            .::.  ...|:  .:.:.:.||...|    |:|:.|..|.|.|...|:|..|.|.|:...||||:
Mouse   370 PYKC--EECGK--CLSSSSCLKRHQPIHSEDKPYKCEDCGRCFCSSSSLRRHQKFHSEGNPYKCE 430

  Fly   508 ICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVHT 555
            .|:..|....:|..|...|||||||.|..|.|.|..:|:|:.|..|||
Mouse   431 KCDKRFSCSGSLQEHQTTHTGEKPYTCENCHKAFCYRSSLRKHKTVHT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		zf-H2C2_2	157..181	CDD:290200	13/23 (57%)
		C2H2 Zn finger	172..192	CDD:275368	6/19 (32%)
		zf-H2C2_2	185..209	CDD:290200	12/23 (52%)
		C2H2 Zn finger	200..220	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		zf-C2H2_8	287..363	CDD:292531	29/75 (39%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..515	CDD:290200	10/23 (43%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		zf-H2C2_2	519..543	CDD:290200	13/23 (57%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
Zfp429	NP_001074410.1	KRAB	15..74	CDD:214630
		KRAB	15..54	CDD:279668
		C2H2 Zn finger	97..113	CDD:275368
		C2H2 Zn finger	121..141	CDD:275368
		zf-H2C2_2	134..158	CDD:290200	7/16 (44%)
		COG5048	144..>461	CDD:227381	116/419 (28%)
		C2H2 Zn finger	149..169	CDD:275368	8/22 (36%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		zf-H2C2_2	189..212	CDD:290200	11/22 (50%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-H2C2_2	273..298	CDD:290200	11/24 (46%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	4/54 (7%)
		C2H2 Zn finger	373..393	CDD:275368	4/23 (17%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-H2C2_2	441..464	CDD:290200	12/22 (55%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100