DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and Meics

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	126/472 - (26%)
Similarity:	176/472 - (37%)	Gaps:	142/472 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GGGG----GGSHTPI---------SPMKQEVQSVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLR 158
            ||||    ||::..:         |..|...:.|...:|  ..|.:|...|..|...||....|.
  Fly   226 GGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKE--QGDTQKPHLCDFCGRGFRTNAQLT 288

  Fly   159 NHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTHKAA 223
            .|.:.||.|||:||..|.||:....||.:|:..|..||...|..|.|.|..:..|..||:.|
  Fly   289 THRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRH--- 350

  Fly   224 ESSTPTSLLNYQ----PQT---GSGKHRKSQMHQAYQQQHQRVQISKTLYSGSYSSPAAEELVKP 281
                 |....|:    |||   .||....|::|:                         ||  :|
  Fly   351 -----TGERPYKCPDCPQTFAKNSGLKLHSRLHK-------------------------EE--RP 383

  Fly   282 FQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQ 346
            |:|.:|.:.|.|...|..|.|.|...:.:||..|||||.:.:.:..|::.|:|.||:.|..|...
  Fly   384 FKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQA 448

  Fly   347 FRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGST 411
            |.....|.:||:.||.: .|......|.|..|                .|.|..
  Fly   449 FSHNHHLKSHLRIHTGE-KPYKCDQCGKGFSA----------------NQSLMK----------- 485

  Fly   412 ANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPF 476
                    |.|.|.                                            ||.||||
  Fly   486 --------HTLWHV--------------------------------------------DNNDRPF 498

  Fly   477 GCSVCQRFFSQQSTLVNHIKTHTG-EKP---YKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFC 537
            .||.|.:.:..|.:|..|.|||.. ::|   ::|..|:|.|....||:.|:..|. .:|:.|..|
  Fly   499 KCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQC 562

  Fly   538 PKQFRQKSTLQNHLRVH 554
            |:.|..:.:|:.|||:|
  Fly   563 PEGFFSQKSLKKHLRLH 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		zf-H2C2_2	157..181	CDD:290200	12/23 (52%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		zf-H2C2_2	185..209	CDD:290200	9/23 (39%)
		C2H2 Zn finger	200..220	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-C2H2_8	287..363	CDD:292531	27/75 (36%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	10/27 (37%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	519..543	CDD:290200	8/23 (35%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	3/19 (16%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	9/31 (29%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	68/266 (26%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	8/24 (33%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	8/24 (33%)
		C2H2 Zn finger	470..486	CDD:275368	5/50 (10%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275370	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030