DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4360 and ZNF728

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001254645.1	Gene:	ZNF728 / 388523	HGNCID:	32463	Length:	622	Species:	Homo sapiens

Alignment Length:	417	Identity:	133/417 - (31%)
Similarity:	176/417 - (42%)	Gaps:	84/417 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 KKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICA 204
            |..:|..|...|.:.:.|..|..|||.|:.|||:.|.|||.:.|:|..|.:.|.||||:.|..|.
Human   226 KPCKCEECGKAFSKFSILTKHKVIHTGEKHYKCEECGKAFTRSSSLIEHKRSHAGEKPYKCEECG 290

  Fly   205 KDFRQQSTLINHIKTHKAAESSTPTSLLNYQ-PQTGSGKHRKSQMHQAYQQQHQRVQISKTLYSG 268
            |.|.:.|||..| ||..|.|..       |: .:.|...:|.|.:     .:|:|:...:
Human   291 KAFSKASTLTAH-KTIHAGEKP-------YKCEECGKAFNRSSNL-----MEHKRIHTGE----- 337

  Fly   269 SYSSPAAEELVKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHT 333
                       ||.:|..|.:.|...|||..|:..|...||||||.|.|:||..::|..||:||.
Human   338 -----------KPCKCEECGKAFGNFSTLTKHKVIHTGEKPYKCEECGKAFSWPSSLTEHKRIHA 391

  Fly   334 GDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQL 398
            |||||.|..|...|:..||||.|...||.:                       .|.......:..
Human   392 GDKPYKCEECGKTFKWSSTLTKHKIIHTGE-----------------------KPYKCEECGKAF 433

  Fly   399 TSGLLPNNLHGSTANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGT 463
            |:             ...|..|.::|             |...:.|.|......|.|..:|....
Human   434 TT-------------FSSLTKHKVIH-------------TGEKHYKCEECGKVFSWSSSLTTHKA 472

  Fly   464 INMLKGDNPDRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTG 528
            |:.     .::.:.|..|.:.|...|.|:.|.:.|||||||||:.|...|.:||.|..|..||||
Human   473 IHA-----GEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKCEECGKAFSKVANLTKHKVIHTG 532

  Fly   529 EKPYNCSFCPKQFRQKSTLQNHLRVHT 555
            ||.|.|..|.|.|...|.|..|.|:||
Human   533 EKQYKCEECGKAFIWSSRLSEHKRIHT 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		zf-H2C2_2	157..181	CDD:290200	13/23 (57%)
		C2H2 Zn finger	172..192	CDD:275368	8/19 (42%)
		zf-H2C2_2	185..209	CDD:290200	11/23 (48%)
		C2H2 Zn finger	200..220	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-C2H2_8	287..363	CDD:292531	37/75 (49%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	491..515	CDD:290200	13/23 (57%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	519..543	CDD:290200	13/23 (57%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368
		COG5048	186..583	CDD:227381	133/417 (32%)
		C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	258..278	CDD:275368	8/19 (42%)
		C2H2 Zn finger	286..306	CDD:275368	10/20 (50%)
		C2H2 Zn finger	314..334	CDD:275368	5/24 (21%)
		zf-H2C2_2	326..349	CDD:290200	6/43 (14%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	355..378	CDD:290200	11/22 (50%)
		C2H2 Zn finger	370..390	CDD:275368	9/19 (47%)
		zf-H2C2_2	382..406	CDD:290200	12/23 (52%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		zf-H2C2_2	411..435	CDD:290200	6/46 (13%)
		C2H2 Zn finger	426..446	CDD:275368	3/32 (9%)
		C2H2 Zn finger	454..474	CDD:275368	4/19 (21%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		zf-H2C2_2	494..518	CDD:290200	12/23 (52%)
		C2H2 Zn finger	510..530	CDD:275368	7/19 (37%)
		zf-H2C2_2	522..545	CDD:290200	12/22 (55%)
		C2H2 Zn finger	538..558	CDD:275368	8/19 (42%)
		zf-H2C2_2	551..574	CDD:290200	5/9 (56%)
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100