DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and Rsl1

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001013791.1	Gene:	Rsl1 / 380855	MGIID:	3044162	Length:	485	Species:	Mus musculus

Alignment Length:	454	Identity:	134/454 - (29%)
Similarity:	188/454 - (41%)	Gaps:	94/454 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 VVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKP 197
            ::.:||....:...||:..  :|..|||:    .|:||||..|.||.....||:.|.::|||:||
Mouse    88 IIPNDPNNCSKLTNCKSLL--ITQRRNHI----GEKPYKCGECGKALSSHKTLSIHQRLHTGDKP 146

  Fly   198 FTCNICAKDFRQQSTLINHIKTHK-----AAESSTPT----SLLNYQPQTGSGKH-------RKS 246
            :.|..|.|.|..:|:|..|:|.|.     ..|....|    |:|....:..||:.       .||
Mouse   147 YKCEECHKAFSTRSSLFIHMKNHTDEKIYKCEDCGRTFYYLSMLKQHQRIHSGEKPYKCEECGKS 211

  Fly   247 QMHQAYQQQHQRVQISKTLYS-----GSYSSP---------AAEELVKPFQCSVCKRRFPQLSTL 297
            ....::.:||||:...|..:.     ..:..|         ..||  ||::|..|.:.|...|.|
Mouse   212 FSFPSFLKQHQRLHCRKNAFKHEQCVNRFPPPLPLQEHEQIRTEE--KPYKCGECYKTFRYHSAL 274

  Fly   298 HNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTH 362
            ..|:..|...:|||||.|.|.||..:.|..|:.:|:.|.||.|..|:..||..|.|..|...||.
Mouse   275 RIHKAVHTGERPYKCEECGKCFSSSSCLKKHQILHSEDNPYKCEECYKAFRNHSALRIHKTVHTG 339

  Fly   363 QIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQLDHHPLLHFLD 427
            : .|......|         ..:|.|:                          .|..|.:||
Mouse   340 E-RPYKCQECG---------KCYSSPS--------------------------CLKRHQILH--- 365

  Fly   428 GSTTVSSVVATAAANT-KVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFFSQQSTL 491
                       :..|. |.|......|.|..:....|::     :.|:|:.|..|.|.|...|:|
Mouse   366 -----------SKYNPYKCEECGKCLSSSSCLKTHQTLH-----SEDKPYKCEDCSRCFCSSSSL 414

  Fly   492 VNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVHT 555
            ..|.|.|:...||||:.|:..|...|.|.:|..||||||||.|..|.|.|..:|:|:.|..|||
Mouse   415 RRHQKFHSEGNPYKCEKCDKRFSCSAGLQDHQTIHTGEKPYRCENCHKAFCYRSSLRKHKTVHT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		zf-H2C2_2	157..181	CDD:290200	11/23 (48%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		zf-H2C2_2	185..209	CDD:290200	11/23 (48%)
		C2H2 Zn finger	200..220	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-C2H2_8	287..363	CDD:292531	30/75 (40%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..515	CDD:290200	10/23 (43%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		zf-H2C2_2	519..543	CDD:290200	14/23 (61%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
Rsl1	NP_001013791.1	KRAB	15..74	CDD:214630
		KRAB	15..54	CDD:279668
		COG5048	91..473	CDD:227381	130/444 (29%)
		C2H2 Zn finger	94..113	CDD:275368	4/20 (20%)
		C2H2 Zn finger	121..141	CDD:275368	7/19 (37%)
		zf-H2C2_2	134..158	CDD:290200	11/23 (48%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		C2H2 Zn finger	177..197	CDD:275368	4/19 (21%)
		zf-H2C2_2	189..213	CDD:290200	5/23 (22%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		zf-H2C2_2	273..298	CDD:290200	11/24 (46%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	5/54 (9%)
		C2H2 Zn finger	373..393	CDD:275368	4/19 (21%)
		C2H2 Zn finger	401..449	CDD:275368	18/47 (38%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100