DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and Zfp553

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001347841.1	Gene:	Zfp553 / 233887	MGIID:	2384725	Length:	591	Species:	Mus musculus

Alignment Length:	588	Identity:	145/588 - (24%)
Similarity:	211/588 - (35%)	Gaps:	194/588 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QHPLVHLLDISTTTANSGG-----------GGGGSHTPISPMKQEVQSVISEEEVVVDDPR---- 139
            :..|...|.:..|:....|           .|.|...|..|:.:           ::.:||
Mouse    24 EEQLAPTLQVGNTSLKPDGIQCWDDLWDRREGLGKRQPRDPVPR-----------ILGEPRWGQG 77

  Fly   140 ---KKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKC--------------KH------------- 174
               :...|..|...|||::.|..|.:.||.|:||||              ||
Mouse    78 SNDRAAVCGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHTGEKAYRVR 142

  Fly   175 -------------------------CDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLI 214
                                     |.|:|||.|.|..|.:.||||||:.|.||.|.|...|..|
Mouse   143 PPAPGPPKMPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARI 207

  Fly   215 NHIKTHKAAESSTPTSLLNYQPQTG--SGKHRKSQMHQAYQQQHQRVQISKTLYSGSYSSPAAEE 277
            .|.:||:..:...|. :...||...  :..||                            |.|::
Mouse   208 KHQRTHRGDQLPRPV-VPRRQPSPAAPAAPHR----------------------------PKAQD 243

  Fly   278 LVKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSY 342
              ||:.|:.|.:||....:|.:|:|:|:.|||:.|:.|.|.|::.:.|..|.::|||:|||.|..
Mouse   244 --KPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPE 306

  Fly   343 CHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNL 407
            |...|...|....||:||:.| .|                  |:.|.  ...:..|:|.||.:.|
Mouse   307 CGKGFADSSARVKHLRTHSGQ-RP------------------HACPE--CNRSFSLSSTLLRHRL 350

  Fly   408 HGSTANIIQLDHHPLLHFLDGST-----TVSSVVATAAANTKVEHFQAGG---SPSGRMTVVGTI 464
            .........|..:|::..:....     |..|:...:.:::....|...|   .|.|...
Mouse   351 THVEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPSHSSDGPFGLPGLEPEPGGPQA----- 410

  Fly   465 NMLKGDNP-----DRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMK 524
                |:.|     |:|..|..|.:.|.:.|.||.|.:.|||||||.|..|...|...:....|::
Mouse   411 ----GEPPPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLR 471

  Fly   525 IHTGE------------KPYN-------------------------CSFCPKQFRQKSTLQNHLR 552
            .|.||            :|:|                         |.||.|:|.:.|.|..|.|
Mouse   472 THQGERTRPPPPPSTLLRPHNPPGSVPIVPQSRVQGRPSGPSQLHVCGFCGKEFPRSSDLVKHRR 536

  Fly   553 VHT 555
            .||
Mouse   537 THT 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		zf-H2C2_2	157..181	CDD:290200	14/75 (19%)
		C2H2 Zn finger	172..192	CDD:275368	11/71 (15%)
		zf-H2C2_2	185..209	CDD:290200	13/23 (57%)
		C2H2 Zn finger	200..220	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-C2H2_8	287..363	CDD:292531	30/75 (40%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	13/23 (57%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		zf-H2C2_2	519..543	CDD:290200	11/60 (18%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
Zfp553	NP_001347841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		145/588 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..80		6/35 (17%)
		C2H2 Zn finger	85..105	CDD:275368	7/19 (37%)
		zf-H2C2_2	97..120	CDD:316026	9/22 (41%)
		C2H2 Zn finger	113..133	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..160		0/28 (0%)
		COG5048	161..572	CDD:227381	119/440 (27%)
		C2H2 Zn finger	165..185	CDD:275368	8/19 (42%)
		C2H2 Zn finger	193..213	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..241		10/63 (16%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	332..352	CDD:275368	6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429		11/65 (17%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..538	CDD:275368	18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..512		6/47 (13%)
		C2H2 Zn finger	546..566	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3714
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950