DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and ZNF626

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001070143.1	Gene:	ZNF626 / 199777	HGNCID:	30461	Length:	528	Species:	Homo sapiens

Alignment Length:	421	Identity:	136/421 - (32%)
Similarity:	175/421 - (41%)	Gaps:	110/421 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 CKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQS 211
            |...|:|.:||..|.||||..:||||:.|.|||....:||.|.||||||||:.|..|.|.|:..|
Human   178 CGKAFKQFSTLTTHKKIHTGGKPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKCEECGKAFKHSS 242

  Fly   212 TLINHIKTHKAAESSTPTSLLNYQPQTGSGKHR-----KSQMHQAYQQQHQRVQISKTLYSGSYS 271
            ||..|.:.|                 ||...::     |:.|..:...:|:.:...|
Human   243 TLTTHKRNH-----------------TGEKPYKCDKCGKAFMSSSTLSKHEIIHTEK-------- 282

  Fly   272 SPAAEELVKPFQCSVCKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDK 336
                    ||::|..|.:.|.:.|||..|:..|...||||||.|||:|....||..||:|||.||
Human   283 --------KPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDK 339

  Fly   337 PYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGG---------GGAVTATVDHSMPAPLA 392
            ||.|..|...|:..||||.|.:.||             |         |.|...:.|
Human   340 PYKCEECGKAFKYSSTLTTHKRIHT-------------GEKPYKCEECGKAFKRSSD-------- 383

  Fly   393 PGTQQLTSGLLPNNLHGSTANIIQLDHHPLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGR 457
                                    |..|.::|             |.....|.|........|..
Human   384 ------------------------LTTHKIIH-------------TGEKPYKCEECGKAFKYSSN 411

  Fly   458 MTVVGTINMLKGDNPDRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNH 522
            :|....|:     ..:||:.|..|.:.|:|.|.|..|.:.|||||.|||:.|...|:..:.|..|
Human   412 LTTHKKIH-----TGERPYKCEECGKAFNQSSILTTHRRIHTGEKFYKCEECGKAFKCSSNLTTH 471

  Fly   523 MKIHTGEKPYNCSFCPKQFRQKSTLQNHLRV 553
            .||||||:||.|..|.|.|.|.|.|..|.|:
Human   472 KKIHTGERPYKCEECGKAFNQSSILTTHERI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	7/16 (44%)
		zf-H2C2_2	157..181	CDD:290200	14/23 (61%)
		C2H2 Zn finger	172..192	CDD:275368	9/19 (47%)
		zf-H2C2_2	185..209	CDD:290200	15/23 (65%)
		C2H2 Zn finger	200..220	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-C2H2_8	287..363	CDD:292531	38/75 (51%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		zf-H2C2_2	519..543	CDD:290200	14/23 (61%)
		C2H2 Zn finger	534..554	CDD:275368	9/20 (45%)
ZNF626	NP_001070143.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	177..195	CDD:275368	7/16 (44%)
		zf-H2C2_2	188..212	CDD:290200	14/23 (61%)
		COG5048	199..520	CDD:227381	126/400 (32%)
		C2H2 Zn finger	203..223	CDD:275368	9/19 (47%)
		zf-H2C2_2	215..240	CDD:290200	15/24 (63%)
		C2H2 Zn finger	231..251	CDD:275368	8/19 (42%)
		zf-H2C2_2	244..266	CDD:290200	6/38 (16%)
		C2H2 Zn finger	259..279	CDD:275368	3/19 (16%)
		zf-H2C2_2	272..296	CDD:290200	7/39 (18%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		zf-H2C2_2	300..324	CDD:290200	13/23 (57%)
		C2H2 Zn finger	315..335	CDD:275368	10/19 (53%)
		zf-H2C2_2	328..352	CDD:290200	13/23 (57%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		zf-H2C2_2	356..380	CDD:290200	8/36 (22%)
		C2H2 Zn finger	371..391	CDD:275368	5/51 (10%)
		zf-H2C2_2	383..408	CDD:290200	7/69 (10%)
		C2H2 Zn finger	399..419	CDD:275368	3/19 (16%)
		zf-H2C2_2	411..436	CDD:290200	7/29 (24%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		zf-H2C2_2	440..464	CDD:290200	12/23 (52%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		zf-H2C2_2	467..492	CDD:290200	14/24 (58%)
		C2H2 Zn finger	483..502	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910