DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4360 and ZNF595

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_872330.1	Gene:	ZNF595 / 152687	HGNCID:	27196	Length:	648	Species:	Homo sapiens

Alignment Length:	460	Identity:	150/460 - (32%)
Similarity:	203/460 - (44%)	Gaps:	84/460 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HTPISPMKQE------VQSVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKC 172
            ||...|.|.|      .:|....|...:....|..:|..|...||..|:|..|..|||.|:||||
Human   250 HTGEKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKPYKC 314

  Fly   173 KHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTH---------KAAESSTP 228
            |.|.|||||..:|..|..|||||||:||..|.|.|.|.|:||.|...|         :..::.|.
Human   315 KECGKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHRSIHSEQKLYKCEECGKAFTW 379

  Fly   229 TSLLNYQPQ--TGSGKHRKSQMHQA-YQQQHQRVQISKTLYSGSYSSPAAEELVKPFQCSVCKRR 290
            :|.||...:  ||...:...:..:| |:..|  :...|.:::|.          ||:.|..|.:.
Human   380 SSSLNKHKRIHTGEKPYTCEECGKAFYRSSH--LAKHKRIHTGE----------KPYTCEECGKA 432

  Fly   291 FPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTN 355
            |.|.|||..|:|.|...||||||.|.|:|::..||..|||||||:|||.|..|...|...::|..
Human   433 FNQSSTLILHKRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCEECGKAFIWSASLNE 497

  Fly   356 HLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQLDHH 420
            |...||.: .|......|.....                    :|||:   :|.|
Human   498 HKNIHTGE-KPYKCKECGKAFNQ--------------------SSGLI---IHRS---------- 528

  Fly   421 PLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFF 485
              :|                :..|:...:..|....|.|.:.  ...|..:.::|:.|..|.:.:
Human   529 --IH----------------SEQKLYKCEECGKAFTRSTALN--EHKKIHSGEKPYKCKECGKAY 573

  Fly   486 SQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNH 550
            :..|||..|.:.||||||:.|:.|...|...::|..|..||||||.|.|..|.|.|.:.|||..|
Human   574 NLSSTLTKHKRIHTGEKPFTCEECGKAFNWSSSLTKHKIIHTGEKSYKCEECGKAFNRPSTLTVH 638

  Fly   551 LRVHT 555
            .|:||
Human   639 KRIHT 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		zf-H2C2_2	157..181	CDD:290200	15/23 (65%)
		C2H2 Zn finger	172..192	CDD:275368	10/19 (53%)
		zf-H2C2_2	185..209	CDD:290200	14/23 (61%)
		C2H2 Zn finger	200..220	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-C2H2_8	287..363	CDD:292531	37/75 (49%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		zf-H2C2_2	519..543	CDD:290200	13/23 (57%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
ZNF595	NP_872330.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..194	CDD:275368
		COG5048	198..599	CDD:227381	129/414 (31%)
		C2H2 Zn finger	202..222	CDD:275368
		C2H2 Zn finger	230..250	CDD:275368	150/460 (33%)
		C2H2 Zn finger	258..278	CDD:275368	3/19 (16%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	10/19 (53%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		C2H2 Zn finger	370..390	CDD:275368	4/19 (21%)
		C2H2 Zn finger	398..418	CDD:275368	4/21 (19%)
		C2H2 Zn finger	426..446	CDD:275368	9/19 (47%)
		C2H2 Zn finger	454..474	CDD:275368	10/19 (53%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	6/54 (11%)
		C2H2 Zn finger	538..558	CDD:275368	4/21 (19%)
		C2H2 Zn finger	566..586	CDD:275368	6/19 (32%)
		C2H2 Zn finger	594..614	CDD:275368	5/19 (26%)
		C2H2 Zn finger	622..642	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100