DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and ZNF681

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_612143.2	Gene:	ZNF681 / 148213	HGNCID:	26457	Length:	645	Species:	Homo sapiens

Alignment Length:	448	Identity:	136/448 - (30%)
Similarity:	184/448 - (41%)	Gaps:	116/448 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HTPISPMKQEV------QSVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKC 172
            ||..:|.|:|.      ||:......::....|..:...|...|.|.:.|..|..|||.|:||||
Human   276 HTGENPYKREECDKAFNQSLTLTTHKIIHTREKLNEYKECGKAFNQSSHLTRHKIIHTGEKPYKC 340

  Fly   173 KHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTHKAAESSTPTSLLNYQPQ 237
            :.|.|||.|.|.||.|..|||||||:.|..|.|.|||.|    |:.|||..             .
Human   341 EECGKAFNQSSHLTRHKIIHTGEKPYRCEECGKAFRQSS----HLTTHKII-------------H 388

  Fly   238 TGSGKHRKSQMHQAYQQQHQRVQISKTLYSGSYSSPAAEELVKPFQCSVCKRRFPQLSTLHNHER 302
            ||...::..:..:|:.:.....: .|::::|.          ||:||..|.:...|.|.|..|:.
Human   389 TGEKPYKCEECGKAFNKSSHLTR-HKSIHTGE----------KPYQCEKCGKASNQSSNLTEHKN 442

  Fly   303 THIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPG 367
            .|.:.||||||.|.|:|:|.:.|..||:||||:|||.|..|...|.|.|.||.|.:.||
Human   443 IHTEEKPYKCEECGKAFNQFSNLTTHKRIHTGEKPYKCEECGKAFNQSSILTTHKRIHT------ 501

  Fly   368 GVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQLDHHPLLHFLDGSTTV 432
                                      |.:...........:.|:    :|..|..:|
Human   502 --------------------------GEKSYKCEECGKAFYRSS----KLTEHKKIH-------- 528

  Fly   433 SSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFFSQQSTLVNHIKT 497
                                                  ..::|:.|..|.:.|:..|.|..|...
Human   529 --------------------------------------TGEKPYTCEECGKAFNHSSHLATHKVI 555

  Fly   498 HTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVHT 555
            |||||||:|:.|...|.|.:.|..|.:||||||||.|..|.|.|.|.|.|..|.::||
Human   556 HTGEKPYQCEECGKAFNQSSHLTRHKRIHTGEKPYQCEKCGKAFNQSSNLTGHKKIHT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		zf-H2C2_2	157..181	CDD:290200	14/23 (61%)
		C2H2 Zn finger	172..192	CDD:275368	10/19 (53%)
		zf-H2C2_2	185..209	CDD:290200	14/23 (61%)
		C2H2 Zn finger	200..220	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-C2H2_8	287..363	CDD:292531	36/75 (48%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	491..515	CDD:290200	12/23 (52%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		zf-H2C2_2	519..543	CDD:290200	14/23 (61%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
ZNF681	NP_612143.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	176..192	CDD:275368
		COG5048	198..610	CDD:227381	134/443 (30%)
		C2H2 Zn finger	200..220	CDD:275368
		C2H2 Zn finger	285..304	CDD:275368	3/18 (17%)
		C2H2 Zn finger	313..332	CDD:275368	5/18 (28%)
		zf-H2C2_2	324..349	CDD:290200	14/24 (58%)
		C2H2 Zn finger	340..360	CDD:275368	10/19 (53%)
		zf-H2C2_2	352..377	CDD:290200	14/24 (58%)
		C2H2 Zn finger	368..388	CDD:275368	11/36 (31%)
		zf-H2C2_2	380..404	CDD:290200	7/36 (19%)
		C2H2 Zn finger	396..416	CDD:275368	2/20 (10%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		zf-H2C2_2	436..461	CDD:290200	12/24 (50%)
		C2H2 Zn finger	452..472	CDD:275368	9/19 (47%)
		zf-H2C2_2	464..489	CDD:290200	13/24 (54%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..517	CDD:290200	6/55 (11%)
		C2H2 Zn finger	508..528	CDD:275368	3/23 (13%)
		zf-H2C2_2	521..545	CDD:290200	7/69 (10%)
		C2H2 Zn finger	536..556	CDD:275368	6/19 (32%)
		zf-H2C2_2	548..573	CDD:290200	12/24 (50%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		zf-H2C2_2	576..601	CDD:290200	14/24 (58%)
		C2H2 Zn finger	592..612	CDD:275368	8/19 (42%)
		C2H2 Zn finger	620..638	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100