DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	521	Identity:	147/521 - (28%)
Similarity:	217/521 - (41%)	Gaps:	125/521 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SVISEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVK 190
            |.|| |.::..:.:|..:|.:|...|.:::.|.||.:|||.|:|:|||.|.|.|.|.|:|..|::
Human   355 SAIS-ESLIGTEGKKFYKCDMCCKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLR 418

  Fly   191 IHTGEKPFTCNICAKDFRQQSTLINHIKTHKAAESSTPTSLLNYQ-PQTGSGKHRKSQM------ 248
            .|:||||:.||.|.|.|.|.:.|:||.:.|        |....|: .:.|.|.:|.|.:
Human   419 NHSGEKPYKCNECGKAFSQSAYLLNHQRIH--------TGEKPYKCKECGKGFYRHSGLIIHLRR 475

  Fly   249 -----------------HQAYQQQHQRVQISKTLYSGSYSSPAAEELVKPFQCSVCKRRFPQLST 296
                             ..||...|||      |:.|.          :|::|:.|::.|....:
Human   476 HSGERPYKCNECGKVFSQNAYLIDHQR------LHKGE----------EPYKCNKCQKAFILKKS 524

  Fly   297 LHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHT 361
            |..|:|.|...|||||:.|.|:|:|...|.:|:::|:.:.||.|..|...|.:..:|..|.:.||
Human   525 LILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYKCKECGKVFIRSKSLLLHQRVHT 589

  Fly   362 HQIAPGGVGGAGGGGGAVTATVDHS-MPAPLAP-----------------GTQQLTSGLLP---- 404
            .: ...|....|....:.:..:||. |.:...|                 ..|:|.:|..|
Human   590 EK-KTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECN 653

  Fly   405 ---------------------NNLH---------GSTANIIQLDHHPLLH--------------- 424
                                 .||:         ||..|:|.   |..||
Human   654 ECGKVFILKKSLILHQRFHTGENLYECKDCGKVFGSNRNLID---HERLHNGEKPYECRECGKTF 715

  Fly   425 FLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFFSQQS 489
            .:..|..|...:.|.....|.|......|.:..:.|...|:     ..::||.||.|.|.||...
Human   716 IMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIH-----TGEKPFECSECGRAFSSNR 775

  Fly   490 TLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVH 554
            .|:.|.:.|:|||||:|..|...|....:|..|.:|||.||.|.|:.|.|.|..:|.|..|.|:|
Human   776 NLIEHKRIHSGEKPYECDECGKCFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIH 840

  Fly   555 T 555
            |
Human   841 T 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		zf-H2C2_2	157..181	CDD:290200	14/23 (61%)
		C2H2 Zn finger	172..192	CDD:275368	9/19 (47%)
		zf-H2C2_2	185..209	CDD:290200	12/23 (52%)
		C2H2 Zn finger	200..220	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-C2H2_8	287..363	CDD:292531	27/75 (36%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		zf-H2C2_2	519..543	CDD:290200	12/23 (52%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..409	CDD:316026	14/24 (58%)
		C2H2 Zn finger	400..420	CDD:275368	9/19 (47%)
		COG5048	424..853	CDD:227381	118/451 (26%)
		C2H2 Zn finger	428..448	CDD:275368	9/19 (47%)
		C2H2 Zn finger	456..476	CDD:275368	4/19 (21%)
		C2H2 Zn finger	484..504	CDD:275368	5/25 (20%)
		C2H2 Zn finger	512..532	CDD:275368	6/19 (32%)
		C2H2 Zn finger	540..560	CDD:275368	7/19 (37%)
		C2H2 Zn finger	568..588	CDD:275368	5/19 (26%)
		C2H2 Zn finger	596..616	CDD:275368	3/19 (16%)
		C2H2 Zn finger	624..644	CDD:275368	1/19 (5%)
		C2H2 Zn finger	652..672	CDD:275368	0/19 (0%)
		C2H2 Zn finger	680..700	CDD:275368	5/22 (23%)
		C2H2 Zn finger	708..728	CDD:275368	2/19 (11%)
		C2H2 Zn finger	736..756	CDD:275368	3/19 (16%)
		COG5048	760..>1026	CDD:227381	37/82 (45%)
		C2H2 Zn finger	764..784	CDD:275368	8/19 (42%)
		C2H2 Zn finger	792..812	CDD:275368	5/19 (26%)
		C2H2 Zn finger	820..840	CDD:275368	8/19 (42%)
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000