DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and KES1

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_015180.1	Gene:	KES1 / 855958	SGDID:	S000006066	Length:	434	Species:	Saccharomyces cerevisiae

Alignment Length:	344	Identity:	105/344 - (30%)
Similarity:	155/344 - (45%)	Gaps:	61/344 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 DLSKVVLPTFILEPRS--------------FLDK--LSDSYYHADLLSKAVQEDDAFTRMKLVVQ 531
            |||.:..|.|||.|.|              ||:.  ::|..|....|.....|.....||..|.:
Yeast    23 DLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTK 87

  Fly   532 WYLSS----FYKKPKGL---KKPYNPILGERFRCYW---QHPSGSRTFYIAEQVSHHPPVSAFYV 586
            |::|:    :..:.:.|   |||.||.|||.|...|   :||....|..::|||||||||:||.:
Yeast    88 WFISTLKSQYCSRNESLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSI 152

  Fly   587 TNRED-----GF-----SITCSILAKSKFYGNSTSAVLEGAATMTLLP-RGECYTATTPYAHCKG 640
            .|.::     |:     |.|.|::...|.:|:            |:|. :.|.|..|.|..|.:|
Yeast   153 FNDKNKVKLQGYNQIKASFTKSLMLTVKQFGH------------TMLDIKDESYLVTPPPLHIEG 205

  Fly   641 ILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKI-------KLGKETLATI 698
            ||:.:..:||.||..|: .:||....:||..:.:..|  ..|....:|       |..::.|.||
Yeast   206 ILVASPFVELEGKSYIQ-SSTGLLCVIEFSGRGYFSG--KKNSFKARIYKDSKDSKDKEKALYTI 267

  Fly   699 NGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQV 763
            :|.|....::..:...||:.||...|...::.|.  :.||:.|...||::.|..|:.||...|..
Yeast   268 SGQWSGSSKIIKANKKEESRLFYDAARIPAEHLN--VKPLEEQHPLESRKAWYDVAGAIKLGDFN 330

  Fly   764 AATEEKTVLEERQRADAKE 782
            ...:.||.|||.||...||
Yeast   331 LIAKTKTELEETQRELRKE 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103
		PH	238..356	CDD:278594
		Oxysterol_BP	471..796	CDD:279564	105/344 (31%)
		Prefoldin	<849..943	CDD:238453
KES1	NP_015180.1	Oxysterol_BP	12..363	CDD:395990	105/344 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770