DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and HES1

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_014880.3	Gene:	HES1 / 854412	SGDID:	S000005763	Length:	434	Species:	Saccharomyces cerevisiae

Alignment Length:	413	Identity:	118/413 - (28%)
Similarity:	184/413 - (44%)	Gaps:	93/413 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 DLSKVVLPTFILEPRS--------------FLD-KLSDSYYHAD-------LLSKAVQEDDAFTR 525
            |||.:..|.|||.|.|              ||: .|.|...:.|       :.||.|      .:
Yeast    23 DLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEV------AQ 81

  Fly   526 MKLVVQWYLSS----FYKKPKGL---KKPYNPILGERFRCYW---QHPSGSRTFYIAEQVSHHPP 580
            |..||:|::|:    :..:.:.:   |||.||.|||.|...|   :||....|..::||||||||
Yeast    82 MLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPP 146

  Fly   581 VSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRG--------ECYTATTPYAH 637
            ::||.:.|.::..|:......|:.|    |..:     |:|:.|.|        |.|..|||..|
Yeast   147 MTAFSIFNEKNDVSVQGYNQIKTGF----TKTL-----TLTVKPYGHVILKIKDETYLITTPPLH 202

  Fly   638 CKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLG-------KETL 695
            .:|||:.:..:||||:..|:..| |....:||..:.:..|  ..|....:|...       :..|
Yeast   203 IEGILVASPFVELGGRSFIQSSN-GMLCVIEFSGRGYFTG--KKNSFKARIYRSPQEHSHKENAL 264

  Fly   696 ATINGHWDKECRV--KDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAI- 757
            ..|:|.|.....:  |||:...:   |...:||.::.|  .:.|::.|...||:|.|:.|:|||
Yeast   265 YLISGQWSGVSTIIKKDSQVSHQ---FYDSSETPTEHL--LVKPIEEQHPLESRRAWKDVAEAIR 324

  Fly   758 -ANEDQVAATEEKTVLEERQRA-DAKERLSSDSVHMPDLFELDSYGQWLYKYADLRPWDSRNDVR 820
             .|...:..|:|:  ||.:||| ..:||:..          ::...:| :|..|....::.|||.
Yeast   325 QGNISMIKKTKEE--LENKQRALREQERVKG----------VEWQRRW-FKQVDYMNENTSNDVE 376

  Fly   821 Q--YECQFKVLT---QTRHKSVP 838
            :  .:..|:.|.   |...|:||
Yeast   377 KASEDDAFRKLASKLQLSVKNVP 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103
		PH	238..356	CDD:278594
		Oxysterol_BP	471..796	CDD:279564	106/364 (29%)
		Prefoldin	<849..943	CDD:238453
HES1	NP_014880.3	Oxysterol_BP	12..365	CDD:395990	108/377 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345159
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740