DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and OSH6

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_012928.1	Gene:	OSH6 / 853872	SGDID:	S000001711	Length:	448	Species:	Saccharomyces cerevisiae

Alignment Length:	434	Identity:	138/434 - (31%)
Similarity:	222/434 - (51%)	Gaps:	47/434 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 EQVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDA 522
            :.::|..|...::|..|:.|:|||.||:::.|||||||.:|.|:::::.....:.|.:|..|.|.
Yeast    38 DDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDP 102

  Fly   523 FTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHPSGSRTFYIAEQVSHHPPVSAFYVT 587
            ..|...|::|||:.::..||.:|||.||:|||.|..||..|:..:.:||:||.|||||..|::..
Yeast   103 LKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYM 167

  Fly   588 NREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLP------RGECYTATTPYAHCKGILMGTL 646
            ..|....:...::.||:|.|||::|:::|:..:..|.      :.|.|..|.|..:.:|||.|.:
Yeast   168 IPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKM 232

  Fly   647 SMELGGKINIECENTGYRTELEFKLKPFLGGA-DATNVVVGKIK-LGKETLATINGHWDKECRVK 709
            .:|||..:.|:..|  ::.::|||.|.::.|. ||   :.|.:| ........|:|.|:....:|
Yeast   233 RIELGDHMIIKSPN--FQADIEFKTKGYVFGTYDA---IEGTVKDYDGNAYYEISGKWNDVMYLK 292

  Fly   710 DSKTGEETVLFKVDAETRSKRLTRYMV-PLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLE 773
            |.|....:.  ||..:|..:...|..| ||..|...||::||::|::|:|..:...|||||..:|
Yeast   293 DLKQPRSSP--KVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIE 355

  Fly   774 ERQRADAKERLSSDSVHMPDLFELDSYGQ----WLYKYADLRPWDSRNDVRQYECQFKVLTQTRH 834
            :.||..||:|:.......|.||.....|:    .:||..   |.|     ...|.|.:.:.|.
Yeast   356 DHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNI---PVD-----EDPEKQIRSILQI-- 410

  Fly   835 KSVPIVHGA-----------EMIHPLRSSIETLSRTQRQSPAGQ 867
              .||:.|.           |.|...:..||    .::|:||.|
Yeast   411 --APILPGQQFTDKFFIPAFEKIKSQKKMIE----NEKQNPAKQ 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103
		PH	238..356	CDD:278594
		Oxysterol_BP	471..796	CDD:279564	116/333 (35%)
		Prefoldin	<849..943	CDD:238453	6/19 (32%)
OSH6	NP_012928.1	Oxysterol_BP	53..393	CDD:395990	118/346 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002062
OrthoInspector	1	1.000	-	-		otm46885
orthoMCL	1	0.900	-	-		OOG6_102132
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1035
TreeFam	1	0.960	-	-
	10	9.770