DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and Osbpl5

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_077251.1	Gene:	Osbpl5 / 79196	MGIID:	1930265	Length:	898	Species:	Mus musculus

Alignment Length:	827	Identity:	390/827 - (47%)
Similarity:	517/827 - (62%)	Gaps:	65/827 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 PSTDSLSNSPA------PSSPGIANWA--SDNRDGNVADKS-AADAAKLNRKESYKAQRKNYRRE 220
            |..|..||.|:      |.:||.|...  ::.|..|.:||. .:...::::|::.|||::|||:|
Mouse    69 PGRDMESNGPSQPRDEEPQTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDALKAQKENYRQE 133

  Fly   221 KKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLT 285
            |||...:|.::|.||:|:::||.||:|||||||||||||||||:|||||:.|.  ..|||||:|.
Mouse   134 KKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKV--GQWVGTVLLH 196

  Fly   286 SCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDA 350
            .|::||||||||||||||||||:||:||.:||..|::|::.||||::||||||.|::.|:||:||
Mouse   197 CCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDA 261

  Fly   351 LELSLRCSALLLRS----------NSSTGTAPTSSYIGEP----------LPVSHETQWSEA--D 393
            |||:||||:||..|          .||...:|:|.| |.|          .|::.....::|  |
Mouse   262 LELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLY-GLPTSATIPDQDLFPLNGSALENDAFSD 325

  Fly   394 YEKHFNDHDLDADSQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFTEEEFGEQGE 458
            ..:..|..|.||::|:.:.....||  |:....|..|.:.         |:||...:||.||..|
Mouse   326 KSERENAEDSDAETQDHSRKTNESG--SDLLDSPGGPWRG---------TTYVEQVQEELGELDE 379

  Fly   459 --QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDD 521
              |||.::||||||:|.:::|:|||||||:||||||:|||||||.||||.|||.||||:|..|||
Mouse   380 TSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFVLEPRSFLGKLSDYYYHGDLLSRAAAEDD 444

  Fly   522 AFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFY 585
            .:.|||||::||||.|||||||:||||||||||.|||.|.|| :.|.||||||||||||||||||
Mouse   445 PYCRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCRWLHPQTNSHTFYIAEQVSHHPPVSAFY 509

  Fly   586 VTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMEL 650
            |:||:|||.::.||.|||||||||.||:|:|.|.:|.|.|.|.||.|.|||||:|||.||::|||
Mouse   510 VSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGILYGTMTMEL 574

  Fly   651 GGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGE 715
            |||:|||||....:.||:||||||.|.:...|.:.|||..|:|.||.:.||||::..:|:..:|.
Mouse   575 GGKVNIECEKNNLQAELDFKLKPFFGSSANINQISGKIMSGEEVLARLTGHWDRDVFIKEESSGG 639

  Fly   716 ETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADA 780
            ..:.:....|.|.:||.|:.|.|:.|...||:||||.|:.||...||..||:||:||||.||..|
Mouse   640 TELFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIREGDQHKATQEKSVLEEAQRQRA 704

  Fly   781 KERLSSDSVHMPDLFELDSYGQ-WLYKYADLRPWDSRNDVRQYECQFKVL----TQTRHKSVPIV 840
            :|...|.:...|.||.||...| |.|:|.||.|||...|:.||| |..:|    .:|.......:
Mouse   705 REHQQSLTPWKPQLFLLDPLTQEWRYRYEDLSPWDPLKDIAQYE-QDGILHTLQRETMSGQTTFL 768

  Fly   841 HGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRDTNSD---SSQSPQGA 902
            ...:..|...||...|.:...|       |.|.|.|.::...:....|..::.|   ..:||...
Mouse   769 GSPDSRHKRPSSDRRLRKASDQ-------PSGHSQVTESSGSTPESCPDLSDEDFVPGGESPCPR 826

  Fly   903 VKRSSSSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPS 949
            .:| ....:|.|..||..:....::..|.|:.:.....|...:|.||
Mouse   827 CRR-EVHRLKMLQEAVLSIQEAQQELHRHLSTMLSSTVRAGQAPAPS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	87/129 (67%)
		PH	238..356	CDD:278594	79/117 (68%)
		Oxysterol_BP	471..796	CDD:279564	195/325 (60%)
		Prefoldin	<849..943	CDD:238453	20/96 (21%)
Osbpl5	NP_077251.1	PH_OPR5_ORP8	144..272	CDD:270103	87/129 (67%)
		PH	151..267	CDD:278594	79/117 (68%)
		Oxysterol_BP	397..730	CDD:279564	199/332 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850024
Domainoid	1	1.000	416	1.000	Domainoid score	I659
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I577
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52510
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	1	1.000	-	-		FOG0002062
OrthoInspector	1	1.000	-	-		otm43827
orthoMCL	1	0.900	-	-		OOG6_102132
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	1	1.000	-	-		X1035
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.700