DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and osbpl11

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_001025662.1	Gene:	osbpl11 / 595054	XenbaseID:	XB-GENE-947934	Length:	731	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	190/676 - (28%)
Similarity:	280/676 - (41%)	Gaps:	195/676 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 IYKSQKT---KSSHWVGTVMLTSCQVIE-----------------------------RPSKKDGF 299
            :||.:.|   :..|||..:.:.:....|                             |||:....
Frog   119 LYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASQGSGNSPGSQRRPSQNAAS 183

  Fly   300 CFKLFH-------------------PLEQSIWAPRGPDKETIGAVVQPLPTA---------YLIF 336
            .|.|.|                   .:.:.:....|..::.:.: ::.||:|         .|:.
Frog   184 FFNLGHHRMVPANRRAQLLQPDHLGDVREMMSKAEGQQRDLMRS-IEGLPSAGHLSSLDQDLLML 247

  Fly   337 RAPSQAAGKCWMDALELSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYE--KHFN 399
            :|.|.|...|..|..::..:....|.|....||||               ..|.||..:  .|.|
Frog   248 KATSMATLSCLNDCFQMLHQQHIALQRHIPPTGTA---------------INWLEAKIQIPNHLN 297

  Fly   400 -------------DHDLDADSQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFTEE 451
                         :.:|..::|..:.:.:.||       :|.:...:|.|:..|      ...|:
Frog   298 NGEESGLALPESQEQELLRETQALSDSTLASG-------EPEDINPEDEVEDGC------DLKED 349

  Fly   452 EFGEQGEQVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADL---L 513
            |.|        ..||.:|:|..::.|::.||||::|||||||||.||.|:..:|...|.||   :
Frog   350 ELG--------AVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFLSHPDLFLSI 406

  Fly   514 SKAVQEDDAFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYWQHPSGSRTF------- 569
            |..:..::   ||...|::||:||::..||  .|||||||:||.|.|.|:.|..|...
Frog   407 SAGLTPEE---RMVRFVEYYLTSFHEGRKGALAKKPYNPIIGETFHCSWRVPKDSLQLSNPTEKP 468

  Fly   570 ----------------------YIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSA 612
                                  ::|||||||||||.||....|....:...|..||||.|.|...
Frog   469 PKAQDQAPLVEDSNKPDSYTIRFVAEQVSHHPPVSGFYAECPERRMCVNTHIWTKSKFMGMSIGV 533

  Fly   613 VLEGAATMTLLPRGECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLG 676
            .:.|...:.||..||.||.|.|.|:.:.||  |:. :|||||:|:.|..:||...:.|..|||.|
Frog   534 TMIGEGVLYLLEHGEEYTFTLPCAYARSIL--TVPWVELGGKVNVNCAKSGYSAAITFHTKPFYG 596

  Fly   677 GA----------DATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRL 731
            |.          :|||.||.|::          |.|:.......|           ..||||..|
Frog   597 GKLHRVTGEVKHNATNSVVCKVQ----------GEWNSVLEFTYS-----------SGETRSIDL 640

  Fly   732 TRYMV------PLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVH 790
            |:..|      |::.|...||:|||:.|:||::.:|...|||.|..|||||||:.:.|..:::..
Frog   641 TKLPVTRKLVRPVEKQGLFESRRLWENVTEALSAKDIERATEHKRALEERQRAEERLRAETETPW 705

  Fly   791 MPDLFELDSYGQWLYKYADLRP-WDS 815
            :...|..:..| |.||    :| |.|
Frog   706 ITKYFTKEGDG-WSYK----QPLWKS 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	23/153 (15%)
		PH	238..356	CDD:278594	23/148 (16%)
		Oxysterol_BP	471..796	CDD:279564	134/375 (36%)
		Prefoldin	<849..943	CDD:238453
osbpl11	NP_001025662.1	PH_ORP10_ORP11	48..154	CDD:270106	7/34 (21%)
osbpl11	NP_001025662.1	Oxysterol_BP	363..725	CDD:366530	139/392 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010