DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and osbpl11

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_689013.3	Gene:	osbpl11 / 560514	ZFINID:	ZDB-GENE-081105-135	Length:	712	Species:	Danio rerio

Alignment Length:	674	Identity:	192/674 - (28%)
Similarity:	274/674 - (40%)	Gaps:	165/674 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 SLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQ 233
            |:::..:.||||..:..|.|      ..:....::|.|..|..:.||:...:....|.|:|...|
Zfish   146 SMASQGSGSSPGSQHRISQN------SNALLGLSQLQRGSSLYSSRKSLLPDHLLEAREMMTQAQ 204

  Fly   234 DPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDG 298
                          |..:.             ||...:...||              :.||
Zfish   205 --------------GQHRD-------------LIQSIEGLPSS--------------QGPS---- 224

  Fly   299 FCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSALLLR 363
                   ||:|.:                      |:.:|.|.|...|..|.|.: |:...:..:
Zfish   225 -------PLDQDL----------------------LLLKATSLATMTCLSDCLHI-LQLQQVARQ 259

  Fly   364 SNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFNDHDLDADSQNEAPNAVMSGLESESESDPA 428
            ....:|  |...::...||          |..|:............:...||:..||.:|.....
Zfish   260 KFPLSG--PALEWLEPKLP----------DILKNGGTLPSITKDDGKTEGAVLEPLEMDSCDIVL 312

  Fly   429 EPAQDDVVDQQCVETSYVPFTEEEFGEQGEQVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFI 493
            |  |:::...|.|:.| .|..||:.|        ..||.:|:|..::.|::.||||::|||||||
Zfish   313 E--QEEIDATQEVDDS-SPSEEEDLG--------AVEEERSVILHLLSQLKLGMDLTRVVLPTFI 366

  Fly   494 LEPRSFLDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERF 556
            ||.||.|:..:|...|.||............||...|::||:||::..||  .|||||||:||.|
Zfish   367 LEKRSLLEMYADFMSHPDLFVAITDGSSPMDRMVRFVEYYLTSFHEGRKGAIAKKPYNPIIGETF 431

  Fly   557 RCYWQHP-----------SGS-------RTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKS 603
            .|.|..|           .||       ...::|||||||||||.||...:|....:...:..||
Zfish   432 HCSWNVPKEAASPTGIPKEGSSCASDCYNVRFVAEQVSHHPPVSGFYAECQERQMCVNTHVWTKS 496

  Fly   604 KFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTEL 667
            ||.|.|....:.|...:.||..||.||.:.|.|:.:.||  |:. :|||||:|:.|..|||...:
Zfish   497 KFMGMSIGVSMIGEGNLNLLEHGEEYTFSLPSAYARSIL--TVPWVELGGKVNVNCAKTGYSAVI 559

  Fly   668 EFKLKPFLGGA----------DATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKV 722
            .|:.|||.||.          :.||.||                    |||:....|.....: .
Zfish   560 TFQTKPFYGGKLHRVNAEVKHNPTNAVV--------------------CRVQGEWNGVLEFAY-T 603

  Fly   723 DAETRSKRLTRYMV------PLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAK 781
            ..|||...:|:..|      |.:||...||:||||.|:|::...|...|||.|..||||||.:.:
Zfish   604 SGETRFVDVTKLPVTRKRVRPNELQGPYESRRLWQHVTESLKERDMDKATEHKRFLEERQRKEER 668

  Fly   782 ERLSSDSVHMPDLFELDSYGQWLY 805
            .|..:.:......||....| |:|
Zfish   669 HRAETQTPWRTKYFERKGEG-WMY 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	19/129 (15%)
		PH	238..356	CDD:278594	17/117 (15%)
		Oxysterol_BP	471..796	CDD:279564	130/361 (36%)
		Prefoldin	<849..943	CDD:238453
osbpl11	XP_689013.3	PH	34..123	CDD:278594
		PH_ORP10_ORP11	35..139	CDD:270106
		Oxysterol_BP	346..691	CDD:279564	133/368 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950