DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and Osbpl5

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_001015024.2	Gene:	Osbpl5 / 361686	RGDID:	1308402	Length:	898	Species:	Rattus norvegicus

Alignment Length:	870	Identity:	391/870 - (44%)
Similarity:	532/870 - (61%)	Gaps:	84/870 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 PSTDSLSNSPA------PSSPGIANWA--SDNRDGNVADKS-AADAAKLNRKESYKAQRKNYRRE 220
            |..|..||.|:      |.:||.|...  ::.|..|.:||. .:...::::|::.|||::|||:|
  Rat    69 PGRDMESNGPSQPRDEEPLTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDTLKAQKENYRQE 133

  Fly   221 KKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLT 285
            |||...:|.::|.||:|:::||.||:|||||||||||||||||:|||||:.|.  ..|||||:|.
  Rat   134 KKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKV--GQWVGTVLLH 196

  Fly   286 SCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDA 350
            .|::||||||||||||||||||:||:||.:||..||:|::.||||::||||||.|::.|:||:||
  Rat   197 CCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGETVGSITQPLPSSYLIFRAASESDGRCWLDA 261

  Fly   351 LELSLRCSALLLRS----------NSSTGTAPTSSYIGEP----------LPVSHETQWSEA--D 393
            |||:||||:||..|          .||...:|:|.| |.|          .|::.....::|  |
  Rat   262 LELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLY-GLPTSATIPDQDLFPLNGSALENDAFSD 325

  Fly   394 YEKHFNDHDLDADSQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFTEEEFGEQGE 458
            ..:..|..|.||::|:.:.....||  |:....|..|.:.         |:||...:||.||..|
  Rat   326 KSERENADDSDAETQDHSRKTNESG--SDLLDSPGGPRRG---------TTYVEQVQEELGELDE 379

  Fly   459 --QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDD 521
              |||.::||||||:|.:::|:|||||||:||||||:|||||||.||||.|||.||||:|..|||
  Rat   380 TSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFVLEPRSFLSKLSDYYYHGDLLSRAAAEDD 444

  Fly   522 AFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFY 585
            .:.|:|||::||||.|||||||:||||||||||.|||.|.|| :.|.||||||||||||||||||
  Rat   445 PYCRIKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWLHPQTNSHTFYIAEQVSHHPPVSAFY 509

  Fly   586 VTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMEL 650
            |:||:|||.::.||.|||||||||.||:|:|.|.:|.|.|.|.||.|.|||||:|:|.||::|||
  Rat   510 VSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGLLYGTMTMEL 574

  Fly   651 GGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGE 715
            |||:.|:||....:.||:||||||.|.:.:.|.:.|||..|:|.||.:.||||::..:|:..:|.
  Rat   575 GGKVTIQCEKNNLQAELDFKLKPFFGSSTSINQISGKITSGEEVLARLTGHWDRDVFIKEEASGG 639

  Fly   716 ETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADA 780
            ..:.:....|.|.:||.|:.|.|:.|...||:||||.|:.||...||..||:||:||||.||..|
  Rat   640 TKLFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIHEGDQHKATQEKSVLEEAQRQRA 704

  Fly   781 KERLSSDSVHMPDLFELDSYGQ-WLYKYADLRPWDSRNDVRQYECQFKVL----TQTRHKSVPIV 840
            :|...|.:...|.||.||...| |.|:|.|..|||...|:.||| |..:|    .:|.......:
  Rat   705 REHQQSLTPWKPQLFTLDPLTQEWRYQYEDYSPWDPLKDIAQYE-QDGILHTLQRETMSGQTAFL 768

  Fly   841 HGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRDTNSD---SSQSPQGA 902
            ...|..|...||...|.:...|       |.|.|.|.::...:....|..::.|   .::||...
  Rat   769 GSPESRHKRPSSDRRLRKASDQ-------PSGHSQVTESSGSTPESCPDLSDEDFVPGNESPCPR 826

  Fly   903 VKRS--SSSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQ 965
            .:|.  ....:::..|::.:..:.|.:|   |:.:.:...|...:|.|             |:.|
  Rat   827 CRREVHRLRMLQEAVLSIQEAQQELHRH---LSAMLRSTVRAGQAPAP-------------GLLQ 875

  Fly   966 STVIKSLIYALIGLAFSLILRWLFK 990
            :.  :|.....|.|...|.:.::.|
  Rat   876 NP--RSWFLLCIFLTCQLFINYILK 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	88/129 (68%)
		PH	238..356	CDD:278594	80/117 (68%)
		Oxysterol_BP	471..796	CDD:279564	191/325 (59%)
		Prefoldin	<849..943	CDD:238453	18/98 (18%)
Osbpl5	NP_001015024.2	PH_OPR5_ORP8	144..272	CDD:270103	88/129 (68%)
		PH	151..267	CDD:278594	80/117 (68%)
		Oxysterol_BP	397..732	CDD:279564	196/334 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353706
Domainoid	1	1.000	416	1.000	Domainoid score	I641
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I552
OMA	1	1.010	-	-		QHG52510
OrthoDB	1	1.010	-	-		D127430at33208
OrthoFinder	1	1.000	-	-		FOG0002062
OrthoInspector	1	1.000	-	-		otm45911
orthoMCL	1	0.900	-	-		OOG6_102132
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1035
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.670