DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and Osbpl10

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_038938606.1	Gene:	Osbpl10 / 316039	RGDID:	1561652	Length:	769	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	227/855 - (26%)
Similarity:	331/855 - (38%)	Gaps:	243/855 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SAGGGTGAGA---------VTPSGLSMGASNQSLGVSV----------GAASSVSGISITPPNSA 139
            ||.||.|.|:         .|.:|.|...|....||:.          |:.||...::.:|....
  Rat     7 SADGGGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVASRSGAAGLGGGGSRSSPGSVAASPSGGG 71

  Fly   140 GLRQSTVFDFKFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKL 204
            |.|          |.|:|:.:::|..:.             :..|  .|| ..|.|..|......
  Rat    72 GRR----------REPALEGVLSKYTNL-------------LQGW--QNR-YFVLDFEAGLLQYF 110

  Fly   205 NRKESYKAQRKNYRREKKRVASELMN---SLQD--PAVIVL----ADWLKVRGTLKSWTKLW--- 257
            ..::|        :.:|.|....|..   ||.|  |.::|:    .:..|:|.......:||
  Rat   111 VNEQS--------KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMYKLRAADSREKQLWVTQ 167

  Fly   258 ---CV---------LKPG-----LLLIYK---------SQKTKSSHWVGTVMLTS---------- 286
               |.         ..||     |.|:..         ||:..|:...|.|.:|.
  Rat   168 LRACAKYHMETSSKTTPGSRSRSLTLLPHGTPSSASPCSQRHLSAGAPGVVSVTRHKSPAAARRA 232

  Fly   287 --------CQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAA 343
                    .:|.|..::.:|....|.|.:|..      |....:.|:.|.|    |:.:|.|.|.
  Rat   233 KSQYSGQLHEVREMMNQVEGQQKNLVHAIESL------PGSGPLTALDQDL----LLLKATSAAT 287

  Fly   344 ----GKCWMDALELSLR----------CSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADY 394
                |:| :..|:.|:|          .|||..|.:.....|    ::....|......|..|..
  Rat   288 LSCLGEC-LTLLQQSVRQAGPPSHKPGASALYFRVHPGMAWA----HVTVHRPTEKWDPWLSALS 347

  Fly   395 EKHFNDHD----------LDADSQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFT 449
            :...|..|          |.|.:::..|..|:|..|.....|..|.....|.||.
  Rat   348 QCQHNLGDSTELGRRGAQLTAGARDSGPELVLSEEEQSDHEDKGEVEPGTVEDQH---------- 402

  Fly   450 EEEFGEQGEQVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLL- 513
                               |:|..::.|::.||||:||||||||||.||.|:..:|...|.|||
  Rat   403 -------------------SVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLL 448

  Fly   514 ---SKAVQEDDAFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYW------------- 560
               :.|..|:    |:...|::||::|::..||  .|||||||:||.|.|.|
  Rat   449 AITAGATPEE----RVISFVEYYLTAFHEGRKGTLAKKPYNPIIGETFHCSWEVPKDRVKSKWTS 509

  Fly   561 --------QHPSG---SRTF---YIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTS 611
                    :||..   |:::   ::|||||||||:|.||...:|....:...:..||||.|.|..
  Rat   510 PHPPISCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVG 574

  Fly   612 AVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFL 675
            ..:.|...:.||..||.|..|.|.|:.:.||  |:. :|||||:||.|..|||...:.|..|||.
  Rat   575 VSMIGEGVLRLLDHGEEYVFTLPSAYARSIL--TVPWVELGGKVNISCAKTGYSATVTFHTKPFY 637

  Fly   676 GGA----------DATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKR 730
            ||.          :.||.:|.|          .:|.|:.......| .||..|:.........|:
  Rat   638 GGKVHRVTAEVKHNPTNTIVCK----------AHGEWNGTLEFTYS-NGETKVIDTTTLPVYPKK 691

  Fly   731 LTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLF 795
            |.    ||:.|...||:.|||.|:..:...|..||||:|..|||:||.:.::|.:..:...|..|
  Rat   692 LR----PLEKQGPMESRNLWQEVTHYLRLGDIDAATEQKRRLEEKQRTEERKRETLRTPWRPKYF 752

  Fly   796 ELDSYGQWLY 805
            ..:..| |:|
  Rat   753 IPEGDG-WVY 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	41/196 (21%)
		PH	238..356	CDD:278594	34/172 (20%)
		Oxysterol_BP	471..796	CDD:279564	130/368 (35%)
		Prefoldin	<849..943	CDD:238453
Osbpl10	XP_038938606.1	PH_ORP10_ORP11	79..185	CDD:270106	22/129 (17%)
Osbpl10	XP_038938606.1	Oxysterol_BP	407..767	CDD:395990	133/377 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920