DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and kes1

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_001342777.1	Gene:	kes1 / 2540206	PomBaseID:	SPBC1271.12	Length:	388	Species:	Schizosaccharomyces pombe

Alignment Length:	419	Identity:	113/419 - (26%)
Similarity:	173/419 - (41%)	Gaps:	66/419 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 TEEEFGEQGEQVEELAEENKSLIWCIVKQVRP-GMDLSKVVLPTFILEPRSFLDKLSDSYYHADL 512
            |..:....||..:.|....||.....:|.:.. ..|||.:..|:|||...|.::..:....|.:|
pombe     5 TSSDDSRDGEGDKRLRSTTKSTWLSFLKSIATFSGDLSSLTAPSFILSSTSLIEYSAYWAEHPEL 69

  Fly   513 LSKAVQEDDAFTRMKLVVQWYLSSF-------YKKPKGLKKPYNPILGERFRCYWQHPSGSRTFY 570
            .....:.:....|..||.:|:.|:.       .::....|||.||||||.|...|....|..|..
pombe    70 FISLPRGETPLERQLLVTKWFASTLKNQYAARNERYGSEKKPLNPILGELFTGKWNTDIGEDTEL 134

  Fly   571 IAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPY 635
            .:||||||||::|:::.|::.|..:......||.|.|........|.|.:.|.|..|.|..|.|.
pombe   135 TSEQVSHHPPITAYHIYNKKAGVRLEGYNGHKSGFSGPQIHVKQIGHARLILEPHNEVYYITFPL 199

  Fly   636 AHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADAT---NVVVGKIKLGKETLAT 697
            ...:|:..|:..:|||.|..| ...:||.|.:|:..|.:..|...|   .:|..|.|  .|.:..
pombe   200 VTLEGLWYGSPYIELGKKSYI-ISTSGYLTTIEYSGKGYFTGKKNTFKATIVNAKTK--SEPIYR 261

  Fly   698 INGHWD---KECRVKDSKTGEETVLFKVDAETRS-----------KRLTRYMVPLDLQEANESQR 748
            |.|.|.   |.|..:|.|              ||           |.:...:.|::.|...||:|
pombe   262 IEGSWTGMLKYCTFEDQK--------------RSAWEDFLDCGNYKPVNISVAPIEEQGEYESRR 312

  Fly   749 LWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLYKYADLRPW 813
            :|:..:.|:...|..||::||:.:||.||...::....:.|             |..||.:   |
pombe   313 VWKNFAVALDAGDYAAASQEKSKIEEGQRELRRQEEEHNEV-------------WHRKYFE---W 361

  Fly   814 DSRNDVRQYECQFKVLTQTRHKSVPIVHG 842
            ..:::  .:|...|.|.|      |:..|
pombe   362 KDKDE--GFEEATKCLRQ------PVKEG 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103
		PH	238..356	CDD:278594
		Oxysterol_BP	471..796	CDD:279564	97/349 (28%)
		Prefoldin	<849..943	CDD:238453
kes1	NP_001342777.1	Oxysterol_BP	28..370	CDD:307410	101/376 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840