DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and obr-3

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_001379311.1	Gene:	obr-3 / 181495	WormBaseID:	WBGene00014215	Length:	770	Species:	Caenorhabditis elegans

Alignment Length:	834	Identity:	368/834 - (44%)
Similarity:	489/834 - (58%)	Gaps:	119/834 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 ISITPPNSAGLRQSTVFDFKF-------KRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDN 188
            ::||.||.         |.:.       :||.||.|...:|.   |.|:||
Worm    10 LTITSPNE---------DMRIVEPPAHKQRRASLSVAYHRLL---SFSSSP-------------- 48

  Fly   189 RDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSW 253
                                 .|.|:|.||.|||||..||:::|:||.|:|:||.||:||.||.|
Worm    49 ---------------------IKKQKKEYRDEKKRVNDELLSALRDPTVVVMADTLKIRGALKRW 92

  Fly   254 TKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPD 318
            .:.:||||||||::||.:|.....|||||:|..|::|||||||||||||||||::.|||..|||.
Worm    93 NRYYCVLKPGLLILYKHKKADRGDWVGTVLLNHCELIERPSKKDGFCFKLFHPMDMSIWGNRGPL 157

  Fly   319 KETIGA-VVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSALLLRS----NSSTGTAPTSSYIG 378
            .::.|: .:.||.|::||.||||..||:|||||||||.:|:.||.::    :...|.:..:....
Worm   158 GQSFGSFTLNPLNTSFLICRAPSDQAGRCWMDALELSFKCTGLLKKTMNELDDKNGDSSMNDGQR 222

  Fly   379 EPLPVSHETQW--------SEADYEKHFNDHDLDADSQNEAPNAVMSGLESESESDPAEPAQDDV 435
            :...:|.::..        ||.|.||||.:.|...|..:|      .|..||:         .|.
Worm   223 DESRMSRDSDGDDTRELAVSETDAEKHFQEIDDVQDEDHE------DGKMSET---------SDT 272

  Fly   436 VDQQCVETSYVPFTEEEFGEQGEQVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFL 500
            :.:...|::::|..:|.||..|...||:.||||||||.::||:||||||||||||||||||||||
Worm   273 IREAFTESAWIPSPKEVFGPDGSLTEEVGEENKSLIWTLLKQIRPGMDLSKVVLPTFILEPRSFL 337

  Fly   501 DKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHPSG 565
            :||:|.||||||:|:||.|.|.|.|:..|.:::||.||||||||||||||||||.|||.|:||.|
Worm   338 EKLADYYYHADLISEAVAEPDPFQRIVKVTKFFLSGFYKKPKGLKKPYNPILGETFRCKWEHPDG 402

  Fly   566 SRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYT 630
            |.|||:|||||||||||:.::|||:.||:|:.:||||||:||||.||:|.|...:|||..||.|.
Worm   403 STTFYMAEQVSHHPPVSSLFITNRKAGFNISGTILAKSKYYGNSLSAILAGKLRLTLLNLGETYI 467

  Fly   631 ATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETL 695
            ...|||:||||::||::|||||::|||||.|||||.|:|||||.|||  |.|.:.|.||.|.:.|
Worm   468 VNLPYANCKGIMIGTMTMELGGEVNIECEKTGYRTTLDFKLKPMLGG--AYNQIEGSIKYGSDRL 530

  Fly   696 ATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANE 760
            |:|.|.||...|:|.....:|  |:....|....||.||.:.:|.|...||.:||:.|:|||:||
Worm   531 ASIEGAWDGVIRIKGPDGKKE--LWNPTPEVIKTRLPRYEINMDEQGEWESAKLWRHVTEAISNE 593

  Fly   761 DQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLYKYADLRPWDSRNDVRQYECQ 825
            ||..||||||.||..|||.||    |...|....|:......::|.:||.||||:.||::|.|..
Worm   594 DQYKATEEKTALENDQRARAK----SGIPHETKFFKKQHGDDYVYIHADYRPWDNNNDIQQIENN 654

  Fly   826 FKVLTQTRHKSVPIVHGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRD 890
            :.|.|.:||......:..::         ....|...|.:.:.:     ..||.|.|.:|.|
Worm   655 YVVKTISRHSKRKTGNSEQL---------GSDNTSEASESDEEV-----IEPKIKKKEIVPA--- 702

  Fly   891 TNSDSSQSPQGAVKRSSSSAIKQL----ALAVDQVNRVLE-QHTRQLNEISQRL 939
              .....:|:.|.:|     ||::    .||:.::....| |.:|.||.|...|
Worm   703 --KSKPITPEVADER-----IKEMERKFELAIRRMEAANERQSSRTLNAIQSTL 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	77/130 (59%)
		PH	238..356	CDD:278594	72/118 (61%)
		Oxysterol_BP	471..796	CDD:279564	194/324 (60%)
		Prefoldin	<849..943	CDD:238453	22/96 (23%)
obr-3	NP_001379311.1	PH_OPR5_ORP8	70..202	CDD:270103	78/131 (60%)
obr-3	NP_001379311.1	Oxysterol_BP	308..631	CDD:395990	195/330 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167190
Domainoid	1	1.000	380	1.000	Domainoid score	I449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68813
Inparanoid	1	1.050	639	1.000	Inparanoid score	I447
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52510
OrthoDB	1	1.010	-	-		D127430at33208
OrthoFinder	1	1.000	-	-		FOG0002062
OrthoInspector	1	1.000	-	-		oto19297
orthoMCL	1	0.900	-	-		OOG6_102132
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	1	1.000	-	-		X1035
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940