DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and OSBPL11

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	NP_073613.2	Gene:	OSBPL11 / 114885	HGNCID:	16397	Length:	747	Species:	Homo sapiens

Alignment Length:	658	Identity:	180/658 - (27%)
Similarity:	269/658 - (40%)	Gaps:	178/658 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 YKSQKT---KSSHWVGTVMLTSCQVIE---------------------------RPSKKDGFCFK 302
            ||.:.|   :..|||..:.:.:....|                           |||:.....|.
Human   133 YKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSSNSPISQRRPSQNAISFFN 197

  Fly   303 LFHPLEQSIWA------------------PRGPDKETIGAVVQPLPTA---------YLIFRAPS 340
            :.|...||:..                  ..|..::.|.. ::.|||:         .|:.:|.|
Human   198 VGHSKLQSLSKRTNLPPDHLVEVREMMSHAEGQQRDLIRR-IECLPTSGHLSSLDQDLLMLKATS 261

  Fly   341 QAAGKCWMDALELSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSE-----ADYEKHFND 400
            .|...|..|...:     ..|..::...|:.|:.:.|          :|.|     :::.|:..|
Human   262 MATMNCLNDCFHI-----LQLQHASHQKGSLPSGTTI----------EWLEPKISLSNHYKNGAD 311

  Fly   401 HDLDADSQ------NEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFTEEEFGEQGEQ 459
            .....|..      .|.|.| .|||.:.   :|.|...||.::..|      ...|::.|
Human   312 QPFATDQSKPVAVPEEQPVA-ESGLLAR---EPEEINADDEIEDTC------DHKEDDLG----- 361

  Fly   460 VEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAFT 524
               ..||.:|:|..::.|::.||||::|||||||||.||.|:..:|...|.||.........|..
Human   362 ---AVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAED 423

  Fly   525 RMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYWQHPS----------------------- 564
            ||...|::||:||::..||  .|||||||:||.|.|.|:.|.
Human   424 RMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLS 488

  Fly   565 -------GSRTF---YIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAAT 619
                   ||..:   ::|||||||||||.||....|....:...:..||||.|.|....:.|...
Human   489 GESLTQVGSDCYTVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGI 553

  Fly   620 MTLLPRGECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGA----- 678
            ::||..||.||.:.|.|:.:.||  |:. :|||||:::.|..|||...:.|..|||.||.
Human   554 LSLLEHGEEYTFSLPCAYARSIL--TVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVT 616

  Fly   679 -----DATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMV-- 736
                 :.||.||.:::          |.|:.......|           :.||:...||:..|
Human   617 AEVKHNITNTVVCRVQ----------GEWNSVLEFTYS-----------NGETKYVDLTKLAVTK 660

  Fly   737 ----PLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFEL 797
                ||:.|:..||:|||:.|::::...:...|||.|..||||||.:.:.|..:.:......|..
Human   661 KRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKHTLEERQRTEERHRTETGTPWKTKYFIK 725

  Fly   798 DSYGQWLY 805
            :..| |:|
Human   726 EGDG-WVY 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	25/149 (17%)
		PH	238..356	CDD:278594	25/144 (17%)
		Oxysterol_BP	471..796	CDD:279564	126/376 (34%)
		Prefoldin	<849..943	CDD:238453
OSBPL11	NP_073613.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		PH_ORP10_ORP11	61..167	CDD:270106	7/33 (21%)
		PH	63..153	CDD:278594	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..188		1/29 (3%)
		Oxysterol_BP	372..732	CDD:279564	128/383 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..714		11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850