DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and OSBPL10

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_005264900.1	Gene:	OSBPL10 / 114884	HGNCID:	16395	Length:	769	Species:	Homo sapiens

Alignment Length:	835	Identity:	221/835 - (26%)
Similarity:	330/835 - (39%)	Gaps:	222/835 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GGGTGAGA-----VTPSGLSMGASNQSLGVSV----------GAASSVSGISITPPNSAGLRQST 145
            |||:.:.:     .|.:|.|...|....|||.          |:.||...::.:|....|.|
Human    11 GGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGGGRR--- 72

  Fly   146 VFDFKFKRRPSLKVLMTKLPS----------------------TDSLSNSPAP----SSPGIANW 184
                   |.|:|:.:::|..:                      .:..|....|    |..|....
Human    73 -------REPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVS 130

  Fly   185 ASD---------NRDGNVADKSAADAAKLNRKESYKAQRK---NYRREKKRVASELMNSLQDPAV 237
            .||         :.:|.:....||||   ..|:.:..|.:   .|..|        |||...|:.
Human   131 LSDEAPHMLVVYSANGEMFKLRAADA---KEKQFWVTQLRACAKYHME--------MNSKSAPSS 184

  Fly   238 IVLADWLKVRGTLKSWTKLWC------VLKPGLLLI-----------YKSQKTKSSHWVGTVMLT 285
            ...:..|...||..|.:.  |      |..||::.|           .|||.:...|
Human   185 RSRSLTLLPHGTPNSASP--CSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLH-------- 239

  Fly   286 SCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDA 350
              :|.|..::.:|....|.|.:|..      |....:.|:.|.|    |:.:|.|.|...|..:
Human   240 --EVREMMNQVEGQQKNLVHAIESL------PGSGPLTALDQDL----LLLKATSAATLSCLGE- 291

  Fly   351 LELSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFNDHDLDADSQNEAPNAV 415
                  |..||.:|....|.........|.:...|.::....:..|:.....|.:.|.|.....:
Human   292 ------CLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAIL 350

  Fly   416 MSGLESESESDP-AEP--------AQDDVVDQQCVETSYVPFTEEEFGEQGEQVEELAEENKSLI 471
            .:..|.|..|.| .||        ::|:..|.:..|       |.|.|        :.|:.:|:|
Human   351 PNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKE-------ETELG--------VMEDQRSII 400

  Fly   472 WCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLL----SKAVQEDDAFTRMKLVVQW 532
            ..::.|::.||||:||||||||||.||.|:..:|...|.|||    :.|..|:    |:...|::
Human   401 LHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEE----RVICFVEY 461

  Fly   533 YLSSFYKKPKG--LKKPYNPILGERFRCYW---------------------QHPSG---SRTF-- 569
            ||::|::..||  .|||||||:||.|.|.|                     :||..   |:::
Human   462 YLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKL 526

  Fly   570 -YIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATT 633
             ::|||||||||:|.||....|....:...:..||||.|.|....:.|...:.||..||.|..|.
Human   527 RFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTL 591

  Fly   634 PYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGA----------DATNVVVGK 687
            |.|:.:.||  |:. :|||||::|.|..|||...:.|..|||.||.          :.||.:|.|
Human   592 PSAYARSIL--TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCK 654

  Fly   688 IKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQR 752
                      .:|.|:..... ....||..|:.........|::.    ||:.|...||:.||:.
Human   655 ----------AHGEWNGTLEF-TYNNGETKVIDTTTLPVYPKKIR----PLEKQGPMESRNLWRE 704

  Fly   753 VSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLYKY 807
            |:..:...|..||||:|..|||:||.:.::|   :::..|          |..||
Human   705 VTRYLRLGDIDAATEQKRHLEEKQRVEERKR---ENLRTP----------WKPKY 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	31/146 (21%)
		PH	238..356	CDD:278594	28/134 (21%)
		Oxysterol_BP	471..796	CDD:279564	126/368 (34%)
		Prefoldin	<849..943	CDD:238453
OSBPL10	XP_005264900.1	PH_ORP10_ORP11	77..183	CDD:270106	20/116 (17%)
		PH	78..171	CDD:278594	14/95 (15%)
		Oxysterol_BP	402..750	CDD:279564	128/379 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850