DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42668 and OSBPL5

DIOPT Version :9

Sequence 1:NP_001189250.2 Gene:CG42668 / 42412 FlyBaseID:FBgn0261550 Length:990 Species:Drosophila melanogaster
Sequence 2:NP_065947.1 Gene:OSBPL5 / 114879 HGNCID:16392 Length:879 Species:Homo sapiens


Alignment Length:881 Identity:396/881 - (44%)
Similarity:532/881 - (60%) Gaps:107/881 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 PSTDSLSNSPAPSSPGIANWA--SDNRDGNVADKS-AADAAKLNRKESYKAQRKNYRREKKRVAS 226
            |:..||.....|.:|..|...  ::.|..|.:||. .:..|::.:||:.|||::|||:||||...
Human    51 PNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATR 115

  Fly   227 ELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIE 291
            :|:::|.||:|:::||.||:|||||||||||||||||:|||||:.|.  ..|||||:|..|::||
Human   116 QLLSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKV--GQWVGTVLLHCCELIE 178

  Fly   292 RPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLR 356
            ||||||||||||||||:||:||.:||..|::|::.||||::||||||.|::.|:||:|||||:||
Human   179 RPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALR 243

  Fly   357 CSALLLRS------NSSTGTAP---TSSYIGEP-----------LPVSHETQWSEA--DYEKHFN 399
            ||:||...      :...||:|   .||..|.|           .|::..:..::|  |..:..|
Human   244 CSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSEREN 308

  Fly   400 DHDLDADSQNEAPNAVMSGLESESESD----PAEPAQDDVVDQQCVETSYVPFTEEEFGEQGE-- 458
            ..:.|.::|:.:       .::||.||    |..|.:..        |:||...:||.||.||  
Human   309 PEESDTETQDHS-------RKTESGSDQSETPGAPVRRG--------TTYVEQVQEELGELGEAS 358

  Fly   459 QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAF 523
            |||.::||||||:|.::||:|||||||:||||||:|||||||:||||.||||||||:|..|:||:
Human   359 QVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAY 423

  Fly   524 TRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVT 587
            :|||||::||||.|||||||:||||||||||.|||.|.|| :.|||||||||||||||||||:|:
Human   424 SRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVS 488

  Fly   588 NREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMELGG 652
            ||:|||.|:.||.|||:|||||.||:|:|.||:|.|.|.|.||.|.|||||||||.||:::||||
Human   489 NRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGG 553

  Fly   653 KINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEET 717
            |:.|||....::.:||||||||.||:.:.|.:.|||..|:|.||:::||||::..:|:..:|...
Human   554 KVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSA 618

  Fly   718 VLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKE 782
            :.:....|.|.:||.::.|||:.|...||:||||.|:.||:..||..||:||..|||.||..|:|
Human   619 LFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARE 683

  Fly   783 RLSSDSVHMPDLFELDSYGQ-WLYKYADLRPWDSRNDVRQYE--------CQFKVLTQT------ 832
            |..|.....|.||.||...| |.|:|.|..|||...|:.|:|        .|..|..||      
Human   684 RQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSP 748

  Fly   833 --RHKSVPIVHGAEMIHPLRSSIETLSRTQRQSPAG--QPLPPGGSAVPKAKNKSLVLAPRDTNS 893
              ||:              ||..:...|.....|:|  |.....||........|      |...
Human   749 GPRHE--------------RSGPDQRLRKASDQPSGHSQATESSGSTPESCPELS------DEEQ 793

  Fly   894 DSSQSPQGAVK----RSSSSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAH 954
            |....|.|...    |..:..::.|..|:..:....::..|.|:.:.....|...:|.|      
Human   794 DGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTP------ 852

  Fly   955 SLHMLGGGVSQSTVIKSLIYALIGLAFSLILRWLFK 990
                   |:.||.  :|.....:.||..|.:..:.|
Human   853 -------GLLQSP--RSWFLLCVFLACQLFINHILK 879

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG42668NP_001189250.2 PH_OPR5_ORP8 231..361 CDD:270103 87/129 (67%)
PH 238..356 CDD:278594 79/117 (68%)
Oxysterol_BP 471..796 CDD:279564 197/325 (61%)
Prefoldin <849..943 CDD:238453 19/99 (19%)
OSBPL5NP_065947.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73 6/21 (29%)
PH_OPR5_ORP8 120..248 CDD:270103 87/129 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..341 19/101 (19%)
Oxysterol_BP 374..709 CDD:307410 202/334 (60%)
Phosphatidylinositol 4-phosphate binding. /evidence=ECO:0000250|UniProtKB:Q02201 384..389 3/4 (75%)
Phosphatidylserine binding. /evidence=ECO:0000250|UniProtKB:Q02201 384..389 3/4 (75%)
Phosphatidylinositol 4-phosphate binding. /evidence=ECO:0000250|UniProtKB:Q02201 446..449 2/2 (100%)