DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42668 and osbpl10

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_002941862.1	Gene:	osbpl10 / 100496082	XenbaseID:	XB-GENE-995970	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	841	Identity:	229/841 - (27%)
Similarity:	355/841 - (42%)	Gaps:	161/841 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SAKQQGAAGGGDTLAHPATPHSHSMPGTPHQQPQSSSVPTGGHLLQLQAPLPSAGGGTGAG---- 102
            :|:||.:.||....:..::..:.|...:|....:...|..|      ...|| ||.|:|:|
Frog     4 AAQQQHSGGGSSNSSSRSSSRATSAGSSPSSAGRGLPVGCG------SGGLP-AGSGSGSGRALQ 61

  Fly   103 -----AVTPSGLSMGASNQSLG------VSVGAASSVSGISITPPN-------SAGLRQSTVFDF 149
                 |:....:..||:..|.|      |..|..|..:.:.....|       .:|:.|..|.:.
Frog    62 QAQAVALAAGKVDGGAAQASKGGREHKQVIEGVLSKYTNLIQGWQNRYFILDFDSGILQYYVTEA 126

  Fly   150 KFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKLNRKESYKAQR 214
            ...::|...:.::  .|..|||.    .:|.:....|.|  |.:....||||   ..::.:..|.
Frog   127 SKNQKPRGSLSLS--GSVISLSE----EAPNVIIVYSTN--GEMYKLRAADA---KERQFWMTQL 180

  Fly   215 K---NYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSS 276
            :   .:..|.|...|:...|..          |...||..|.:.           ..:.|.|.|.
Frog   181 QACAKFHSESKSAVSQRARSYS----------LLPHGTSNSPSP-----------ASQRQMTHSG 224

  Fly   277 HWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQ 341
            ..:.||.........|.||.....  ..|.:::.:....|..|..:.|:              ..
Frog   225 PSIVTVTHHKSPAAARRSKNQNPA--QLHEVKEVMAQVEGQQKNLVHAI--------------ES 273

  Fly   342 AAGKCWMDALELSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFND------ 400
            .:|...:.||:..|    |||::.|    |.|.|.:||.|.:..::.:......|:.:.
Frog   274 LSGSGPLSALDQDL----LLLKATS----AATLSCLGECLHLLQQSVYQSGQNNKNISTDSILSW 330

  Fly   401 HDLDADSQNEAPNAVMSGLESESESD------PAEPAQDDVVDQQCVETSYVPFTEEEFGEQGEQ 459
            |...:.|.....|..:|.|.| |:::      |:.| ||..|.::..||. .|..|||..:..:.
Frog   331 HGPKSHSTENLKNGHLSSLPS-SDTNLTWPIIPSMP-QDYKVLERDTETG-PPEAEEELTDTEDN 392

  Fly   460 VEE---LAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDD 521
            .||   :.::.:|:|..::.|::.||||:||||||||||.||.|:..::...|.||.........
Frog   393 EEEDLGVMDDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYANFMAHPDLFLSIAAGAT 457

  Fly   522 AFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYWQHP--------------------- 563
            ...|:...|::||::|::..||  .||||||:|||.|.|.|..|
Frog   458 PEERIICFVEYYLTAFHEGRKGAVAKKPYNPVLGETFHCSWDVPKENVKSFRTQSASKETVPPPS 522

  Fly   564 -SGS--RTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPR 625
             ||.  :..::|||||||||||.||...:|....:...:..||||.|.|....:.|...:.|:..
Frog   523 SSGEAYKLRFVAEQVSHHPPVSCFYCECKEKKMCVNAHVWTKSKFLGMSVGVSMVGEGILRLMEH 587

  Fly   626 GECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGA----------D 679
            ||.|..|.|.|:.:.||  |:. :|||||:||.|..|||...:.|..|||.||.          :
Frog   588 GEEYVFTLPSAYARSIL--TVPWVELGGKVNISCAKTGYVATVIFHTKPFYGGKVHRVTAEVKHN 650

  Fly   680 ATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEAN 744
            .||.:|.|.:          |.|:.......| |||.    |:...|:...:.:.:.||:.|...
Frog   651 PTNTMVCKAQ----------GEWNGTLEFTYS-TGET----KLIDTTKLLNIKKKIRPLEKQGQC 700

  Fly   745 ESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLY 805
            ||:|:|:.|:.|:.:.:..||:|:|..|||||||::::|.|.::...|..|..:..| |.|
Frog   701 ESRRVWENVTNALKSGNIEAASEQKHQLEERQRAESRQRASLNTTWKPKYFIKEGEG-WAY 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	21/129 (16%)
		PH	238..356	CDD:278594	19/117 (16%)
		Oxysterol_BP	471..796	CDD:279564	127/361 (35%)
		Prefoldin	<849..943	CDD:238453
osbpl10	XP_002941862.1	PH_ORP10_ORP11	91..197	CDD:270106	23/116 (20%)
osbpl10	XP_002941862.1	Oxysterol_BP	409..766	CDD:366530	130/370 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920