DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and osbpl10b

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_005158298.1	Gene:	osbpl10b / 100319820	ZFINID:	ZDB-GENE-081002-4	Length:	752	Species:	Danio rerio

Alignment Length:	763	Identity:	204/763 - (26%)
Similarity:	310/763 - (40%)	Gaps:	191/763 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 NRDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKS 252
            :|.|:.:..|||.:      :::.:|      .:||....::|              |....|:.
Zfish    28 SRSGSYSPGSAAVS------DTHPSQ------SQKRHLEGVLN--------------KYTNLLQG 66

  Fly   253 WTKLWCVLKP--GLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDGFCFKL------FHPL-- 307
            |...:.||.|  |.|..:.::.:|.....|::.|....|  .||.:..|.|.:      |..|
Zfish    67 WQNRYFVLDPELGQLQYFINEHSKVQKPRGSLPLIGSSV--APSDEFPFMFTVCAANGDFFKLRA 129

  Fly   308 ----EQSIW-------APRGPDKETIGAV-------------------VQPLPTAYLI------- 335
                ||.:|       |.|..|....|..                   ..|:|....|
Zfish   130 SDVREQQMWMTQLQLCARRHSDGNAKGCSSSSSSSTSSTGRTRSFSLHPHPVPQNSFISAQKQSP 194

  Fly   336 -------------FRAP---------------------SQAAG--KCWMDALE--------LSLR 356
                         .|:|                     |||.|  |..::::|        .||.
Zfish   195 QHGTPASVISITHHRSPTGGQRACSRNPAGLHQVKEVMSQAEGQQKNLVNSIESLPSRGPLSSLD 259

  Fly   357 CSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFNDHDLDAD--------SQNEAPN 413
            ...|||::.|    |.|.|.:||.|.:........|.:..|.:.:..:.:        |:::..|
Zfish   260 QDLLLLKATS----AATLSCLGECLSLLQHNVCQAAQHITHGHPNTGENNSWSRPKTASEDQMKN 320

  Fly   414 AVMSGLESESESDPAEP---AQDDVVDQQCVETSYVPFTEEEFGEQGEQVEELA--EENKSLIWC 473
            ..:....:.:...|..|   :::.:.|::......|..:||....:..:.|:|.  ::.:|:|..
Zfish   321 GELMCNNTSARHQPHSPIHRSKERLKDKENSSPESVDSSEEITDTEDNEEEDLGVLDDQRSVILH 385

  Fly   474 IVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHAD----LLSKAVQEDDAFTRMKLVVQWYL 534
            ::.|::.||||::|||||||||.||.|:..::...|.|    :.|.|..|:    ||...|::||
Zfish   386 LLSQLKLGMDLTRVVLPTFILEKRSLLEMYANFMAHPDVFLAITSGATPEE----RMIRFVEYYL 446

  Fly   535 SSFYKKPKG--LKKPYNPILGERFRCYWQHPS-------------------------------GS 566
            ::|::..||  .||||||||||.|.|.|..|.                               ||
Zfish   447 TAFHEGRKGAVAKKPYNPILGESFHCTWDVPREKVRPLRTTSSSPAPAAAAAHSAQTSSNEGLGS 511

  Fly   567 -RTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYT 630
             |..::|||||||||||.||...:|....:...:..||||.|.|....:.|...:.||...|.|.
Zfish   512 YRLRFVAEQVSHHPPVSGFYCECKERRICVNTHVWTKSKFMGMSIGVSMVGEGVLHLLDHDEQYV 576

  Fly   631 ATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKE- 693
            .|.|.|..:.||  |:. :|||||::|.|..:||...:.|..|||.||  ..:.|..::|....
Zfish   577 FTLPSAFARSIL--TVPWVELGGKVSISCAKSGYSATVTFHTKPFYGG--KVHRVTAEVKHNPSG 637

  Fly   694 -TLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAI 757
             .:....|.|:..... ...:||..|:.........|::.    |||.|...||:||||:|:.|:
Zfish   638 TIVCKAQGEWNGTLEF-TYNSGETKVIDTSKLPVIKKKIR----PLDKQGQYESRRLWQQVTTAL 697

  Fly   758 ANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLY 805
            ...|...|||.|..||||||.:.|:|.:|.|...|..|..:..| |:|
Zfish   698 KAGDIDEATEHKHQLEERQRREGKQRSASSSSWKPKYFIKEGEG-WVY 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	38/220 (17%)
		PH	238..356	CDD:278594	37/208 (18%)
		Oxysterol_BP	471..796	CDD:279564	130/365 (36%)
		Prefoldin	<849..943	CDD:238453
osbpl10b	XP_005158298.1	PH_ORP10_ORP11	53..155	CDD:270106	25/117 (21%)
		PH	54..147	CDD:278594	22/108 (20%)
		Oxysterol_BP	385..744	CDD:279564	132/372 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850