Protein Alignment Orp8 and osbpl10b

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: XP_005158298.2
• Gene: osbpl10b / 100319820
• ZFINID: ZDB-GENE-081002-4
• Length: 752
• Species: Danio rerio
• Alignment Length: 783
• Identity: 210/783 - (26%)
• Similarity: 316/783 - (40%)
• Gaps: 192/783 - (24%)

  Fly   169 SLSNSPAPSSPGIANWAS-DNRDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSL 232
            |.|......|..:.|.|. .:|.|:.:..|||.:      :::.:|      .:||....::|
Zfish     8 SHSGGSKGKSADLGNPAQRQSRSGSYSPGSAAVS------DTHPSQ------SQKRHLEGVLN-- 58

  Fly   233 QDPAVIVLADWLKVRGTLKSWTKLWCVLKP--GLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSK 295
                        |....|:.|...:.||.|  |.|..:.::.:|.....|::.|....|  .||.
Zfish    59 ------------KYTNLLQGWQNRYFVLDPELGQLQYFINEHSKVQKPRGSLPLIGSSV--APSD 109

  Fly   296 KDGFCFKL------FHPL------EQSIW-------APRGPDKETIGAV---------------- 325
            :..|.|.:      |..|      ||.||       |.|..|....|..
Zfish   110 EFPFMFTVCAANGDFFKLRASDVREQQIWMTQLQLCARRHSDGNAKGCSSSSSSSTSSTGRTRSF 174

  Fly   326 ---VQPLPTAYLI--------------------FRAP---------------------SQAAG-- 344
               ..|:|....|                    .|:|                     |||.|
Zfish   175 SLHPHPVPQNSFISAQKQSPQHGTPASVISITHHRSPTGGQRACSRNPAGLHQVKEVMSQAEGQQ 239

  Fly   345 KCWMDALE--------LSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFNDH 401
            |..::::|        .||....|||::.|    |.|.|.:||.|.:........|.:..|.:.:
Zfish   240 KNLVNSIESLPSRGPLSSLDQDLLLLKATS----AATLSCLGECLSLLQHNVCQAAQHITHGHPN 300

  Fly   402 DLDAD--------SQNEAPNAVMSGLESESESDPAEP---AQDDVVDQQCVETSYVPFTEEEFGE 455
            ..:.:        |:::..|..:....:.:...|..|   :::.:.|::......|..:||....
Zfish   301 TGENNSWSRPKTASEDQMKNGELMCNNTSARHQPHSPIHRSKERLKDKENSSPESVDSSEEITDT 365

  Fly   456 QGEQVEELA--EENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHAD----LLS 514
            :..:.|:|.  ::.:|:|..::.|::.||||::|||||||||.||.|:..::...|.|    :.|
Zfish   366 EDNEEEDLGVLDDQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYANFMAHPDVFLAITS 430

  Fly   515 KAVQEDDAFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYWQHPS------------- 564
            .|..|:    ||...|::||::|::..||  .||||||||||.|.|.|..|.
Zfish   431 GATPEE----RMIRFVEYYLTAFHEGRKGAVAKKPYNPILGESFHCTWDVPREKVRPLRTTSSSP 491

  Fly   565 ------------------GS-RTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNST 610
                              || |..::|||||||||||.||...:|....:...:..||||.|.|.
Zfish   492 APAAAAAHSAQTSSNEGLGSYRLRFVAEQVSHHPPVSGFYCECKERRICVNTHVWTKSKFMGMSI 556

  Fly   611 SAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPF 674
            ...:.|...:.||...|.|..|.|.|..:.||  |:. :|||||::|.|..:||...:.|..|||
Zfish   557 GVSMVGEGVLHLLDHDEQYVFTLPSAFARSIL--TVPWVELGGKVSISCAKSGYSATVTFHTKPF 619

  Fly   675 LGGADATNVVVGKIKLGKE--TLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVP 737
            .||  ..:.|..::|....  .:....|.|:..... ...:||..|:.........|::.    |
Zfish   620 YGG--KVHRVTAEVKHNPSGTIVCKAQGEWNGTLEF-TYNSGETKVIDTSKLPVIKKKIR----P 677

  Fly   738 LDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQ 802
            ||.|...||:||||:|:.|:...|...|||.|..||||||.:.|:|.:|.|...|..|..:..|
Zfish   678 LDKQGQYESRRLWQQVTTALKAGDIDEATEHKHQLEERQRREGKQRSASSSSWKPKYFIKEGEG- 741

  Fly   803 WLY 805
            |:|
Zfish   742 WVY 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	39/220 (18%)
		Oxysterol_BP	471..817	CDD:460126	134/376 (36%)
osbpl10b	XP_005158298.2	None