DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42668 and osbpl5

DIOPT Version :9

Sequence 1:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster
Sequence 2:	XP_001345022.3	Gene:	osbpl5 / 100006189	ZFINID:	ZDB-GENE-030131-5872	Length:	865	Species:	Danio rerio

Alignment Length:	903	Identity:	415/903 - (45%)
Similarity:	564/903 - (62%)	Gaps:	109/903 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 FKRRPSLKVLMTKLPSTD------SLS----NSPAPSSPGIANWASDN-----RD--------GN 192
            |:||.||....|..|..|      :||    |...|.|||  |....|     ||        .:
Zfish     7 FRRRFSLCPTATSPPKIDPRVLTRNLSYGGDNELYPLSPG--NETERNGLPLLRDEVSPARSPSS 69

  Fly   193 VAD---------KSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRG 248
            |::         :|::...||.||||.|.|:||||:||||||.||.::|:||:|:::::|||:||
Zfish    70 VSESRMFIGLEKESSSPTEKLARKESLKVQKKNYRQEKKRVAKELFSALKDPSVVIMSNWLKIRG 134

  Fly   249 TLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWA 313
            ||||||||||||:||:|:|||:  ..|.|||||::|.:|::||||||||||||||:||:::||||
Zfish   135 TLKSWTKLWCVLRPGILIIYKT--PGSDHWVGTILLNACKLIERPSKKDGFCFKLYHPMDKSIWA 197

  Fly   314 PRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSALLLRSNSS-----TGTAPT 373
            .:||:.||:|::.||||:.||||||.|::.|:||||||||:|.||:|...:..|     ..::..
Zfish   198 MKGPEGETVGSITQPLPSNYLIFRAASESDGRCWMDALELALSCSSLSKMTAKSCRDGDLSSSSE 262

  Fly   374 SSYIGEPLPVSHETQWSEADYE-KHFNDHDLDADSQNEAPNAVMSGLESESESDPA--------- 428
            ||:|.:.|..|..|     |.| ...||..|:.:.:|:| |:..|..|:..:||.|
Zfish   263 SSHILQLLQSSALT-----DQELLQLNDSMLENNMENDA-NSDKSEREAHEDSDNAANENGGRLT 321

  Fly   429 EPAQDDVVDQQCVE-TSYVPFTEEEFGEQGE--QVEELAEENKSLIWCIVKQVRPGMDLSKVVLP 490
            |.:..|..|..|:: |.:|....||.||.||  |||.:::|||.|||.::||:||||||||||||
Zfish   322 EESDMDQSDDVCLQATGFVEEAHEEMGEAGEASQVETVSDENKGLIWTLLKQLRPGMDLSKVVLP 386

  Fly   491 TFILEPRSFLDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGER 555
            |||||||||||||||.|||||||||||.|:..:.|||.|::||||.||||||||||||||||||.
Zfish   387 TFILEPRSFLDKLSDYYYHADLLSKAVTEESPYGRMKQVLRWYLSGFYKKPKGLKKPYNPILGEM 451

  Fly   556 FRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAAT 619
            |||.|.|| :.|.||||||||||||||||||::|::|||.|:.||||||||||||.||:|:|.|.
Zfish   452 FRCCWLHPQTDSCTFYIAEQVSHHPPVSAFYISNKKDGFCISGSILAKSKFYGNSLSAILDGKAR 516

  Fly   620 MTLLPRGECYTATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVV 684
            :..|.|.|.|..|.|||||||||.||:::||||||.||||.|...||||||||||||.:...|.:
Zfish   517 LLFLTRDEEYVITMPYAHCKGILYGTMTLELGGKITIECEKTQCYTELEFKLKPFLGSSCNVNQI 581

  Fly   685 VGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRL 749
            .|||::|::.|||:.||||.:..:.:.|||.:.||:....:.|.:||.:.:||:|.|||.||:||
Zfish   582 SGKIRIGEDILATVEGHWDSKVHLIEKKTGHQEVLWNPGPDIRRQRLKKRVVPIDQQEAFESERL 646

  Fly   750 WQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDS-YGQWLYKYADLRPW 813
            ||.|::||.::||..||:||.||||.||.:|:||  ::....|.||.||: ..:|.||:||.:||
Zfish   647 WQHVTQAINDKDQNRATQEKFVLEEAQRQEARER--AERAWNPRLFTLDADTNEWHYKHADTKPW 709

  Fly   814 DSRNDVRQYE----CQFKVLTQTRHKSVPIVH---GAEMIHPLRSSIETLSRTQRQSPAGQPLPP 871
            |....:.|:|    .|.|..:|.|........   |.:.:.        ::...|:| :.||
Zfish   710 DPERCLVQFEKDGIIQTKEKSQRRRNRYSYSQDWAGQQKVR--------VNGKHRKS-SSQP--- 762

  Fly   872 GGSAVPKAKNKSLVLAPRDTNSDSSQSPQGAVKRSS--SSAIKQLAL---AVDQVNRVLEQHTRQ 931
             .|.....::.|....|...:||:    :|.:.:.:  |..:|.:||   :|..:.:..:...|.
Zfish   763 -SSCSQNTESSSTTPEPNHESSDN----EGFMNQCARCSKEVKDIALIEASVAAIQKTQQDIQRN 822

  Fly   932 LNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTVIKSLIYALIGLAFSLILRWLF 989
            |:.:.:::.|.:.:....|:|....               ||..:: |.|.|::..:|
Zfish   823 LSALGRQIARHKTAEESKSLSGRHF---------------LILCML-LLFQLLINHVF 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	83/129 (64%)
		PH	238..356	CDD:278594	76/117 (65%)
		Oxysterol_BP	471..796	CDD:279564	207/325 (64%)
		Prefoldin	<849..943	CDD:238453	18/98 (18%)
osbpl5	XP_001345022.3	PH_OPR5_ORP8	117..246	CDD:270103	84/130 (65%)
		PH	124..240	CDD:278594	76/117 (65%)
		Oxysterol_BP	367..701	CDD:279564	211/335 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595862
Domainoid	1	1.000	418	1.000	Domainoid score	I628
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I631
OMA	1	1.010	-	-		QHG52510
OrthoDB	1	1.010	-	-		D127430at33208
OrthoFinder	1	1.000	-	-		FOG0002062
OrthoInspector	1	1.000	-	-		oto41374
orthoMCL	1	0.900	-	-		OOG6_102132
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1035
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.810