Protein Alignment MELTF and Tsf2

DIOPT Version :10

• Sequence 1: XP_011511152.1
• Gene: MELTF / 4241
• HGNCID: 7037
• Length: 765
• Species: Homo sapiens
• Sequence 2: NP_524044.1
• Gene: Tsf2 / 39435
• FlyBaseID: FBgn0036299
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 849
• Identity: 275/849 - (32%)
• Similarity: 397/849 - (46%)
• Gaps: 177/849 - (20%)

Human    25 WCATSDPEQHKCGNMSEA-------FREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAI 82
            ||..|..||:||.|::.|       |.|..:  :|.|....|||.|:..|..::|...|||.|.:
  Fly    35 WCTKSQAEQYKCQNLTVAIERDRALFDEVFL--NLTCFMAYSADECIHHIDREKAHITTLDAGDV 97

Human    83 YEAGKEHGLKPVVGEVYDQEVG-TSYYAVAVVRRSSHVTIDTLKGVKS---CHTGINRTVGWNVP 143
            :.||:.:.|.|::.|  ..|.| ..|.:|||:::.|...::.|:.:::   |...:....||.||
  Fly    98 FTAGRYNSLIPIMQE--KLEGGFADYQSVAVIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVP 160

Human   144 VGYLVESGRLSVMGC-DVLKAVSDYFGGSCVPGAGETSY------SESLCRLCRGDSSGEGVCDK 201
            :..|...|.:.|:.| :.:|..:.||..||...:....:      |:.||.||.|...| |.|
  Fly   161 IHTLQREGGMEVVDCNNQVKTAASYFNNSCAVYSLSDKHNPIGDNSDKLCTLCTGKIPG-GRC-- 222

Human   202 SPLERYYDYSGAFRCLAEGAGDVAFVKHSTV---LENTDGKTLPSWGQALLSQDFELLCRDGSRA 263
            |..:.|:.|.|||:||.| .|||||::||||   |:.|:.|.       :....||||||||.||
  Fly   223 SSADPYFGYEGAFKCLLE-KGDVAFLRHSTVNEMLQTTEFKN-------IAPDTFELLCRDGRRA 279

Human   264 DVTEWRQCHLARVPAHAVV---VRADTD--------------------------GGLIFRLLN-- 297
            .:.::|||:..:|||.|:|   .|:.:|                          ||..|...|
  Fly   280 SINDYRQCNWGQVPADAIVTSSARSFSDRKQYQQFLKRIAELYSDGTRDDQSRQGGQSFNSRNNI 344

Human   298 ------------------------EGQRL---FSHEGS------------SFQMFSSEAYGQKDL 323
                                    ..:||   |:.|.:            .|::|.|:.||:.:|
  Fly   345 NDQNAYGQFDNNDPYRTQNQYDQYRSERLDSSFAEERNQQDGTNTSILYEKFRIFESKRYGKPNL 409

Human   324 LFKDSTSEL--VPIATQTYEAWLGH--EYLHAMKGLLCDPNRLP-PYLRWCVLSTPEIQKCGDMA 383
            ||:||:..|  :|...|::..:||.  .:::.::       ..| |.:..||.|..|:.||..|.
  Fly   410 LFQDSSRALTVIPEDDQSFTKYLGPAINFIYGIR-------ECPVPAMTLCVTSENELDKCIKMR 467

Human   384 VAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHY---APE 445
            .|.:...||||:.|....|..:||:.|:|.:.|.......|:||.|..|.|||...|.|   .||
  Fly   468 TALKAHLLKPELICKKMHSHINCMQFIEAGKADISVFDAGDVYTGGLNYDLVPFMSEVYNLGEPE 532

Human   446 DSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAV 510
                 ||||||.:.|.... .|..|:||.:||.|..:.|||..|:...|..|:|||..||.:.|.
  Fly   533 -----YYVVAVAKEDDPDT-ELTYLKGKNTCHTGINTAAGWTYPMALFISNGWIRPYGCDSVRAA 591

Human   511 SEFFNASCVP--VNNPKN----YPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGD 569
            :|:|..||||  ::|..|    | .|:|.||.|...  ..|..::.|.|||:.||||||||..|.
  Fly   592 AEYFTKSCVPGAISNEYNTGVPY-DSMCDLCHGTSY--RYCRRDASEEYYGHTGAFRCLVEGGGH 653

Human   570 VAFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVR---- 630
            |||::||||.::|.|...|.||....::|:||||.:|.|||:..:..|||.::..:||:.|
  Fly   654 VAFMKHTTVMESTGGKRKEWWARNALNDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVN 718

Human   631 -PDTNIFTVYGLLDKAQQFAASGTGRVTLPEPSEEQVVCLRCFQDLFGDDHNKNGFKMFDSSNYH 694
             .:|.:.....||..|||.    .||..:               |.|       .|.||.|...|
  Fly   719 YNETQMNAYINLLTYAQQL----YGRKEV---------------DAF-------SFSMFSSPIGH 757

Human   695 GQDLLFKDAT--VRAVPVGEKTTYRGWLGLDYVAALEGMSSQQC-SGAAAPAPGAPLLPLLLPAL 756
             .||:|:|||  ::.:| ..|..|..:||.|::.|   .....| :||:..|....|  ||:.:|
  Fly   758 -YDLIFQDATRQLQVIP-PNKRRYDAYLGSDFMRA---RRITDCYAGASQLALSVGL--LLVGSL 815

Human   757 AARL 760
            .|.|
  Fly   816 VAML 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MELTF	XP_011511152.1	Transferrin	23..357	CDD:395328	123/426 (29%)
		TR_FER	367..733	CDD:214514	140/381 (37%)
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	104/351 (30%)
		PBP2_transferrin	450..792	CDD:270247	140/381 (37%)