Protein Alignment MELTF and Tsf3

DIOPT Version :10

• Sequence 1: XP_011511152.1
• Gene: MELTF / 4241
• HGNCID: 7037
• Length: 765
• Species: Homo sapiens
• Sequence 2: NP_523759.1
• Gene: Tsf3 / 36800
• FlyBaseID: FBgn0034094
• Length: 714
• Species: Drosophila melanogaster
• Alignment Length: 769
• Identity: 170/769 - (22%)
• Similarity: 271/769 - (35%)
• Gaps: 168/769 - (21%)

Human     9 WLLLALRTVLGG-MEVRWCATSDPEQHKCGNMSEAFREA-GI-------------QPSLLCVRGT 58
            ||.|.|..:... :.:..|....|...  |.:.....|: |:             :.::.||.|.
  Fly     3 WLTLILVGLFASFLSISMCVAVQPPDD--GKLRVCVVESRGVYRKTPKFCPLLEAKSNIECVIGV 65

Human    59 SADHCVQ----------------LIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSY 107
            ....||:                |:||:.|....|                |..|:...|....|
  Fly    66 DRLDCVRRIHKGTAHFGVLTSEDLVAARWASVEIL----------------VASELRSHESHFEY 114

Human   108 YAVAVVRRSSHV-TIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSD----- 166
            ..||||...::: |:..|:|.:.||.|......|...:....|:..:| ..||....|::
  Fly   115 EIVAVVDNHANIHTVHDLRGARLCHPGYGLGNHWTEVLANYFEAAMVS-KTCDPEMTVTEDRIAS 178

Human   167 ---YFGGSCVPGAGETSYSE---------SLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAE 219
               |||.||..|.......:         |||.:|....|    ||::  ::::...||..||..
  Fly   179 TAKYFGPSCKAGPWVPDPKQDRILKNRYPSLCEMCYEPDS----CDQT--DKHWGRRGALYCLTS 237

Human   220 GAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVR 284
            |.|:||:.:...|..:.....:|:...   ..||..||.||....:...:.|.....|...|..|
  Fly   238 GGGNVAWARLDDVRSHFGFSGIPAQSN---PSDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAAR 299

Human   285 ADTDGGLIFRLLNEGQRLFSHEGSSFQ---MFSSEAYGQKDLLFKDSTSELVPI------ATQTY 340
            . :....:.||:.   .|...|..|:|   :...|.|.    :|......::.|      ||...
  Fly   300 R-SHAAQVQRLVT---GLNHDEPDSWQNALLSLLETYH----VFTVPLDNVIAIDDYLDQATAFQ 356

Human   341 EAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQH 405
            .|:...|         |:|   |..:.:|..|..:..||..:..|.:...::|.||||.....|.
  Fly   357 SAYSFPE---------CNP---PRSIVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQQ 409

Human   406 CMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDEL 470
            |::..:.::.|.|.:..|....|.:.|.|||...|..|  |..:.|..:|:|.:|:... :..:|
  Fly   410 CLDNTKFKETDVVLVDQEMRVKAQRDYNLVPLLYEFAA--DMHDRYVTIALVHKDAKFE-SFRDL 471

Human   471 RGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALC 535
            :|.|:|...|...|...|....:...|.::        ::..:|:...                |
  Fly   472 KGARACLPSFEGAAHLSVQETIVNATGKVQ--------SLHSYFHRDS----------------C 512

Human   536 VGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE 600
            :.:.|...||    ...|.|..||.|||.|.| ||||:..........|:.:..|......:|:.
  Fly   513 LWNLQSGRKC----PLHYQGDEGALRCLSEGA-DVAFLSSDVYKKYVVGNLTSNWLTPGNHKDFR 572

Human   601 LLCPNGARAEVSQFAACNLAQIPPHAVMV--------------------------RPDTNIFTVY 639
            :|||.|...:.|.|..|.|.......:|.                          :.:|..||:|
  Fly   573 VLCPYGGIEKRSNFEYCYLHWTTRGHLMTHNSSLTRRNEIYNSLRDMDQLFGRKYKSETRPFTLY 637

Human   640 GLLDKAQQ--FAASGTGRVTLPEPSEEQVVCLRCFQDLFGDDHNKNGFKMFDSS 691
            |:.||...  |.....|.:.|.|...:.  ..|..:.::....|...::.||.|
  Fly   638 GIFDKRNNVLFRDDTDGLLGLQELHRDN--AKRVMEHIYDRYANTQYYRNFDES 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MELTF	XP_011511152.1	Transferrin	23..357	CDD:395328	82/390 (21%)
		TR_FER	367..733	CDD:214514	81/353 (23%)
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	81/380 (21%)
		PBP2_transferrin	369..681	CDD:270247	78/345 (23%)