Protein Alignment MELTF and Tsf1

DIOPT Version :10

• Sequence 1: XP_011511152.1
• Gene: MELTF / 4241
• HGNCID: 7037
• Length: 765
• Species: Homo sapiens
• Sequence 2: NP_523401.2
• Gene: Tsf1 / 32821
• FlyBaseID: FBgn0022355
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 164/759 - (21%)
• Similarity: 277/759 - (36%)
• Gaps: 229/759 - (30%)

Human     9 WLLL---ALRTVLGGME-------VRWCATSDPEQH--KCGNMSEAFREAGIQPSLLCVRGTSAD 61
            ||.|   ||..:||...       .|.|.   |:.:  :|..:.....||||:  :.||.|....
  Fly    10 WLPLAVAALLLILGPQSSLAEEPIYRLCV---PQIYLAECQQLLADPSEAGIR--MECVAGRDRV 69

Human    62 HCVQLIAAQEADAITLDGGAIYEA--GKEHGLKPVVGEV---YDQEVGTSYYAVAVVRRSSHV-T 120
            .|::||..::||.:..:...:|.|  .|....: |:.|:   .|::....|..:.:|::.|.: |
  Fly    70 DCLELIEQRKADVLATEPEDMYIAYHRKNEDYR-VISEIRTQQDKDAAFRYEGIILVKKDSPIRT 133

Human   121 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCD--------VLKAVSDYFGGSCVPGAG 177
            :..|:|.||||||..|.||:.:|:..|..:..|.| ..|        .||::|::|..||:.|..
  Fly   134 LQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKV-SADPQISATERELKSLSEFFTQSCLVGTY 197

Human   178 ET----------SYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTV 232
            .|          .|: :||.||.....    |:..  :::..|.||.|||.:|.|:|||.|...:
  Fly   198 STHPETDRLLKKKYA-NLCALCEKPEQ----CNYP--DKFSGYDGAIRCLDKGQGEVAFSKVQYI 255

Human   233 -----LENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLI 292
                 |........|:.|.   .::||.||.||:|..|| ...|..|:.|....:...
  Fly   256 KKYFGLPGAGPDAPPAEGN---PENFEYLCEDGTRRPVT-GPACSWAQRPWSGYISNE------- 309

Human   293 FRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLC 357
             :.::..::|...:....:.|::....|.    ||:.:.|:......|.:          |....
  Fly   310 -QAVHNSEQLHQLQSRLERFFANGLQAQN----KDAAAHLLIQPNAVYHS----------KDAAI 359

Human   358 DPNRLPPYL-------------------RWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSP 403
            ||.   .||                   |.|..:..|..||..:..|...:..:||::||.:..
  Fly   360 DPK---VYLERAGYKDVIERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTD- 420

Human   404 QHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAV----VRRDSSHA 464
              |:..:..::.| :|:.....|...::..|.|...|..|.:|     .:|||    |.|::
  Fly   421 --CVVALTKKEAD-LTIVRATGYADARSNQLQPIVYEQRAQDD-----VLVAVAAPGVTREA--- 474

Human   465 FTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPS 529
                                         :|:..|:             ||.:|        ..|
  Fly   475 -----------------------------LQKASIK-------------FNENC--------ERS 489

Human   530 SLCALCVGDEQGRNKC-VGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAE 593
            ...|..:...:|.:.| |.:|.:                |:|..|.                |:|
  Fly   490 RAAAALLNKRRGLDACRVSSSDD----------------GEVQIVP----------------ASE 522

Human   594 L-RSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDT------------------------ 633
            | :.:|.:|:||:..|..|:.|..||:....|.|:.:|.||
  Fly   523 LEKHKDAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDKFGARGK 587

Human   634 --NIFTVYGLLDKAQQFAASGTGRVTLPEPSEEQVVCLRCFQDL 675
              ::|.::|...|.::........|.|....:.::...:.:.||
  Fly   588 LVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIYTDL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MELTF	XP_011511152.1	Transferrin	23..357	CDD:395328	91/364 (25%)
		TR_FER	367..733	CDD:214514	62/341 (18%)
Tsf1	NP_523401.2	TR_FER	34..323	CDD:214514	84/314 (27%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:473866	59/324 (18%)