DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg4 and CES2

DIOPT Version :9

Sequence 1:NP_001369025.1 Gene:Nlg4 / 42402 FlyBaseID:FBgn0083975 Length:1437 Species:Drosophila melanogaster
Sequence 2:NP_001352334.1 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:655 Identity:180/655 - (27%)
Similarity:271/655 - (41%) Gaps:174/655 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 VEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEY 131
            |:.|||:|:|.||....||:|...|..|.|:|....:..:|.|.|..:::|.          |..
Human    55 VQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEF----------LSQ 109

  Fly   132 LKRLLPFLENQSEDCLYLNVFSPVNA--GANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEV 194
            .....| .::.|||||||::::|.::  |:|   |||:|:|||.:..:...:.||||:||:...|
Human   110 FNMTFP-SDSMSEDCLYLSIYTPAHSHEGSN---LPVMVWIHGGALVFGMASLYDGSMLAALENV 170

  Fly   195 VVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGA 259
            |||.:.||||:|||.:.. :.||   ..|:|.:||:|||.|:||||..|||:|:.||:.|...|.
Human   171 VVVIIQYRLGVLGFFSTG-DKHA---TGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGG 231

  Fly   260 ACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVD 324
            ..::.|:.|| :.:||||.||:.||.|.....:.....:.:..:|....|...|.     |.:|.
Human   232 TSVSSLVVSP-ISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDS-----EALVG 290

  Fly   325 CLRDVPLEDLYLADIQAPNFLTSFGPS-VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAG 388
            |||....|     :|.|.|......|. ||||.: |.|.    .:|:|      |||  ||....
Human   291 CLRGKSKE-----EILAINKPFKMIPGVVDGVFL-PRHP----QELLA------SAD--FQPVPS 337

  Fly   389 GGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFE 453
                                                      :.||...|..|..          
Human   338 ------------------------------------------IVGVNNNEFGWLI---------- 350

  Fly   454 GERRDKIIRTY------VRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTR---DTAVA----AL 505
                .|::|.|      .|.|....|.::...::...|..|...:..|...   .|..|    .:
Human   351 ----PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMM 411

  Fly   506 SDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK--D 568
            :|:.||.|.::......:.:|                              .|||.|.:|..  .
Human   412 ADSMFVIPALQVAHFQCSRAP------------------------------VYFYEFQHQPSWLK 446

  Fly   569 GDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNY---TKSETALSEAVMIFWTNFARTGNPNEHH 630
            ...|..|...||::||::|.       |.|..||   |:.|..||..:|.:|.||||.||||   
Human   447 NIRPPHMKADHGDELPFVFR-------SFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPN--- 501

  Fly   631 RQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMED 695
              ...||           .|..:|. .::||::.::|.:....:||:|..|.:.:|:..:. :|:
Human   502 --GEGLP-----------HWPLFDQ-EEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQE-LEE 551

  Fly   696 VIARH 700
            ...||
Human   552 PEERH 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg4NP_001369025.1 COesterase 43..681 CDD:395084 175/634 (28%)
CES2NP_001352334.1 COesterase 30..538 CDD:306613 175/634 (28%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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