Protein Alignment Nlg4 and CES2

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_003860.3
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 180/655 - (27%)
• Similarity: 271/655 - (41%)
• Gaps: 174/655 - (26%)

  Fly    67 VEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEY 131
            |:.|||:|:|.||....||:|...|..|.|:|....:..:|.|.|..:::|.          |..
Human    55 VQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEF----------LSQ 109

  Fly   132 LKRLLPFLENQSEDCLYLNVFSPVNA--GANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEV 194
            .....| .::.|||||||::::|.::  |:|   |||:|:|||.:..:...:.||||:||:...|
Human   110 FNMTFP-SDSMSEDCLYLSIYTPAHSHEGSN---LPVMVWIHGGALVFGMASLYDGSMLAALENV 170

  Fly   195 VVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGA 259
            |||.:.||||:|||.:.. :.||   ..|:|.:||:|||.|:||||..|||:|:.||:.|...|.
Human   171 VVVIIQYRLGVLGFFSTG-DKHA---TGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGG 231

  Fly   260 ACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVD 324
            ..::.|:.|| :.:||||.||:.||.|.....:.....:.:..:|....|...|.     |.:|.
Human   232 TSVSSLVVSP-ISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDS-----EALVG 290

  Fly   325 CLRDVPLEDLYLADIQAPNFLTSFGPS-VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAG 388
            |||....|     :|.|.|......|. ||||.: |.|.    .:|:|      |||  ||....
Human   291 CLRGKSKE-----EILAINKPFKMIPGVVDGVFL-PRHP----QELLA------SAD--FQPVPS 337

  Fly   389 GGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFE 453
                                                      :.||...|..|..
Human   338 ------------------------------------------IVGVNNNEFGWLI---------- 350

  Fly   454 GERRDKIIRTY------VRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTR---DTAVA----AL 505
                .|::|.|      .|.|....|.::...::...|..|...:..|...   .|..|    .:
Human   351 ----PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMM 411

  Fly   506 SDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK--D 568
            :|:.||.|.::......:.:|                              .|||.|.:|..  .
Human   412 ADSMFVIPALQVAHFQCSRAP------------------------------VYFYEFQHQPSWLK 446

  Fly   569 GDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNY---TKSETALSEAVMIFWTNFARTGNPNEHH 630
            ...|..|...||::||::|.       |.|..||   |:.|..||..:|.:|.||||.||||
Human   447 NIRPPHMKADHGDELPFVFR-------SFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPN--- 501

  Fly   631 RQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMED 695
              ...||           .|..:|. .::||::.::|.:....:||:|..|.:.:|:..:. :|:
Human   502 --GEGLP-----------HWPLFDQ-EEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQE-LEE 551

  Fly   696 VIARH 700
            ...||
Human   552 PEERH 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	175/634 (28%)
CES2	NP_003860.3	COesterase	30..538	CDD:395084	175/634 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559		1/1 (100%)