DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Ces1h

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001357759.1	Gene:	Ces1h / 75704	MGIID:	1922954	Length:	562	Species:	Mus musculus

Alignment Length:	703	Identity:	197/703 - (28%)
Similarity:	294/703 - (41%)	Gaps:	179/703 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFL 71
            :.|..|:||....::|            .|......:|.|.:|::.|..:.|:.  |.:.|.|||
Mouse     1 MCLYALILLSLSAMAW------------GGYPSSPPVVNTTHGKVLGKYISLEG--FTQPVAVFL 51

  Fly    72 GVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQR--LPNIQNETAALEKMPKGRLEYLKR 134
            |||:|.||....||:|.:.|.||..::.:..|.|:|.|.  |..:.|: ..:....|.||.:
Mouse    52 GVPFAKPPLGSLRFAPPQPPEPWSFVKNATSYPPMCSQDAVLGQMVND-LIINNKEKIRLRF--- 112

  Fly   135 LLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTL 199
                    |||||||||::||:...|..:|||:|:|||........:.|||..|:::..|||||:
Mouse   113 --------SEDCLYLNVYTPVDLMKNTNRLPVMVWIHGGGLVVGGASAYDGRTLSAHENVVVVTI 169

  Fly   200 NYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINY 264
            .|||.|.||.:....   |:| .|:|.:||:|||||||.||..|||||.|||:.|...|...::.
Mouse   170 QYRLAIWGFFSTGDE---HSR-GNWGHLDQLAALHWIQDNIANFGGDPGSVTIFGQSAGGESVSV 230

  Fly   265 LMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNC-TIPDDINRHHEQIVDCLRD 328
            |:.|| :.:.||||||..||..::|...:||......::|....| |....:      ||.|||.
Mouse   231 LVLSP-LAKNLFHRAISQSGVVFTSGLFMEDASSVTEQIAVTAGCKTTTSAV------IVHCLRQ 288

  Fly   329 VPLEDLYLADIQAPNFLT-----------SFGPSV-DGVVIRPGHSNLDIDDLMARNSRRSSADS 381
            ...|:| |..:|..|...           .|.|:| ||||:......:    |..:|........
Mouse   289 KTEEEL-LEIMQKMNLFKLDAQENTKKNYPFLPTVLDGVVLPKAPEAI----LAEKNFNTVPYIV 348

  Fly   382 GFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAH 446
            |...                     ..||         .|:.|               |..|...
Mouse   349 GINK---------------------QEFG---------WTLPM---------------IMEFPPT 368

  Fly   447 DIQNGFEGERRDKIIRTYVRN-AYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQF 510
            |:      :...|:|..::|. ||.:::.|....:..|  .:.:.:..||..|...:..:.|..|
Mouse   369 DV------KLDKKVISLFLRKLAYFFNIPEDGIPVAIE--KYSKGTDDPIQNRVWLLQLIGDVMF 425

  Fly   511 VAP--IVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGD--- 570
            ..|  ||..|             ...||:|                    .|::::|::...
Mouse   426 GIPSVIVSRG-------------HRDAGAP--------------------TYMYEFQSRPSFSSE 457

  Fly   571 -YPQRMGTVHGEDLPYIFGAPLV-DGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQD 633
             .|:.:...||:::..:||||:: :|.|       :.|..||:.:|.||.||||.||||     .
Mouse   458 LKPKTVTGDHGDEVYSVFGAPILREGSS-------EEEINLSKMMMKFWANFARNGNPN-----G 510

  Fly   634 SSLPVSKERNRFRSITWENYDPLHQK--YLEIGMKPRIKNHFRAHQLSIWLRL 684
            ..||           .|..|   :||  ||:||...:.....:..::|:|..|
Mouse   511 QGLP-----------HWPEY---NQKKGYLQIGATTQQAQGLKDKEVSLWTEL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	189/662 (29%)
Ces1h	NP_001357759.1	COesterase	24..546	CDD:365897	189/663 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810