DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg4 and TG

DIOPT Version :9

Sequence 1:NP_001369025.1 Gene:Nlg4 / 42402 FlyBaseID:FBgn0083975 Length:1437 Species:Drosophila melanogaster
Sequence 2:NP_003226.4 Gene:TG / 7038 HGNCID:11764 Length:2768 Species:Homo sapiens


Alignment Length:729 Identity:187/729 - (25%)
Similarity:278/729 - (38%) Gaps:223/729 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 YGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAP--WDGIRISDKYSPVCPQR 110
            :|||.|....:......:.|:.|||||||.||..:.||   :||.|  |.|...:.|....|.| 
Human  2206 HGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRF---QAPEPLNWTGSWDASKPRASCWQ- 2266

  Fly   111 LPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHG--- 172
             |..:..|:                    ...||||||||||.|.|...|..   |:||.|.   
Human  2267 -PGTRTSTS--------------------PGVSEDCLYLNVFIPQNVAPNAS---VLVFFHNTMD 2307

  Fly   173 --ESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHW 235
              ||..|.:   .|||.||:.|.::|||.:||:|:.|||::.....:    .|:||:||:|||.|
Human  2308 REESEGWPA---IDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVS----GNWGLLDQVAALTW 2365

  Fly   236 IQQNIQKFGGDPNSVTLAGHGTGAACIN-YLMTSPTMVRGLFHRAILMSGSAYSSWALV--EDPV 297
            :|.:|:.|||||..|:||....||...: :|:|:......||.||:||.|||.|..|::  |...
Human  2366 VQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQ 2430

  Fly   298 LFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTS-----FGPSVDGVVI 357
            ..||.|||||:|.:...     :::|.|||..|..  .|.|.|......|     :||.:||..:
Human  2431 QQAIALAKEVSCPMSSS-----QEVVSCLRQKPAN--VLNDAQTKLLAVSGPFHYWGPVIDGHFL 2488

  Fly   358 R--PGHS---NLDID-DLMARNSR------RSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFG 410
            |  |..:   :|.:: ||:..:|:      |:.|...|:.|.|                      
Human  2489 REPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRG---------------------- 2531

  Fly   411 GGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNE 475
                     .|.:....|..|                 ||...||  |...|......:.|.|..
Human  2532 ---------RTSSKTAFYQAL-----------------QNSLGGE--DSDARVEAAATWYYSLEH 2568

  Fly   476 IFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGA 540
                ..::|..:.|..::.  |||..:        :.||:   |:                   |
Human  2569 ----STDDYASFSRALENA--TRDYFI--------ICPII---DM-------------------A 2597

  Fly   541 NAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGE-----DLPYIFGAPLVDGFSHFPQ 600
            :|.|..:.|:          ||.|..     |:..|  ||.     |:.:..|.|.   :..:..
Human  2598 SAWAKRARGN----------VFMYHA-----PENYG--HGSLELLADVQFALGLPF---YPAYEG 2642

  Fly   601 NYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPL--HQKYLEI 663
            .::..|.:||..:|.::::|.|:||||..:.....:|..       :..|.::.|.  .:.|.|.
Human  2643 QFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTF-------ATPWPDFVPRAGGENYKEF 2700

  Fly   664 GMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAG 728
            ......:...:....|.|.:.|..|.                                  ::|.|
Human  2701 SELLPNRQGLKKADCSFWSKYISSLK----------------------------------TSADG 2731

  Fly   729 ASGSSSSSSSSSRL 742
            |.|..|:.|....|
Human  2732 AKGGQSAESEEEEL 2745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg4NP_001369025.1 COesterase 43..681 CDD:395084 177/666 (27%)
TGNP_003226.4 TY 33..92 CDD:238114
TY 95..160 CDD:238114
TY 300..358 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..545
Thyroglobulin_1 599..658 CDD:395039
Thyroglobulin_1 662..724 CDD:395039
TY 729..>776 CDD:412186
TY <892..922 CDD:412186
TY 1004..1073 CDD:238114
TY 1077..1145 CDD:238114
TY 1149..1210 CDD:238114
Type II. /evidence=ECO:0000269|PubMed:8797845 1456..1469
Ephrin_rec_like 1465..1510 CDD:400166
Type II. /evidence=ECO:0000269|PubMed:8797845 1470..1486
Type II. /evidence=ECO:0000269|PubMed:8797845 1487..1503
TY 1520..1567 CDD:214561
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1603..1723
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1724..1892
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1893..1995
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1996..2129
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 2130..2187
Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710 2188..2768 187/729 (26%)
COesterase 2197..2718 CDD:395084 177/666 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2727..2768 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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