Protein Alignment Nlg4 and Ces1a

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001177304.1
• Gene: Ces1a / 679817
• RGDID: 1583671
• Length: 563
• Species: Rattus norvegicus
• Alignment Length: 709
• Identity: 188/709 - (26%)
• Similarity: 283/709 - (39%)
• Gaps: 194/709 - (27%)

  Fly    22 WMHCAGASTADIYKGARLGH----RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQ 82
            |:.....::.:.|..  .||    .:|.|..|::.|..:.|:.  |.:.|.||||||:|.||...
  Rat     2 WLFALALTSLNTYMA--FGHPSSPPVVDTLQGKVLGKYISLEG--FTQPVAVFLGVPFAKPPLGS 62

  Fly    83 NRFSPTRAPAPWDGIRISDKYSPVCPQ--RLPNIQNE--TAALEKMPKGRLEYLKRLLPFLENQS 143
            .||:|.:....|..::.:..|.|:|.|  .:..:.:|  |..||.:|   |||           |
  Rat    63 LRFAPPQPAESWSFVKNATSYPPMCSQITGVGPVLSEVFTNQLENVP---LEY-----------S 113

  Fly   144 EDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGF 208
            |||||||::||.:. .::.:|||:|::||........:.:||..|:::.:||||.:.|||||.||
  Rat   114 EDCLYLNIYSPTDL-TSKDRLPVMVWVHGGGLLSGGASTFDGLALSTHEKVVVVVIQYRLGIWGF 177

  Fly   209 LNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVR 273
            |:....   |:| .|:|..||:|||.|:|.||..||||||||||.|...|...::.|:.|| :.:
  Rat   178 LSTGDE---HSR-GNWGHFDQVAALQWVQNNIVNFGGDPNSVTLFGESAGGESVSVLVLSP-LTK 237

  Fly   274 GLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDL---- 334
            .||||||..||.|.:.....|:..|.|.::|....|......:     ||.|||:...|:|
  Rat   238 NLFHRAISESGVALTPCLFRENTRLAAEQVAIATGCAATTSAD-----IVRCLREKTEEELLATT 297

  Fly   335 -----YLADI-----QAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGG 389
                 :..|:     ::..|||:.   :|||             |:.:......::..|.:..
  Rat   298 LKMKFFALDLHGDPRESYPFLTTV---IDGV-------------LLPKAPEEILSEKNFNTVP-- 344

  Fly   390 GGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGES----------IWRFS 444
                                   |.  .|......|.....:.|....||          :|:
  Rat   345 -----------------------YI--VGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWK-- 382

  Fly   445 AHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTD-WDRTSQHPINTRDTAVAALSDA 508
                                     :|.|..|...:....|: :...|..|...:|..:..:.|.
  Rat   383 -------------------------SYPLTNISKELTPVATEKYLGGSDCPDKKKDLFLDMMGDV 422

  Fly   509 QFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK--DGDY 571
            .|..|.|    |:|...              .:|.|:|           |.|.|.|...  ....
  Rat   423 LFAVPSV----IVARYH--------------RDARATT-----------YVYEFKYHPSFVSDMR 458

  Fly   572 PQRMGTVHGEDLPYIFGAP-LVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSS 635
            |:.:...||:::..::|.| |.:|.|       :.|..||..:|.||.||||.||||     ...
  Rat   459 PKTVIADHGDEVYSVWGTPFLKEGAS-------EEEINLSTMMMKFWGNFARNGNPN-----GEG 511

  Fly   636 LPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGME 694
            ||           .|..||. .:.||:||...:.....:..:::.|..|      .|||
  Rat   512 LP-----------HWPEYDE-KESYLQIGTTIQQAQKLKYKEVAFWTGL------RGME 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	179/669 (27%)
Ces1a	NP_001177304.1	COesterase	22..545	CDD:395084	179/672 (27%)