DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg4 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	194/725 - (26%)
Similarity:	301/725 - (41%)	Gaps:	201/725 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRS-VEV 69
            |||||            :|..|..:.:       ...|..|..|::.|   .||..:..:: |..
  Rat    17 LLLLL------------IHVQGQHSPE-------SSPIRNTHIGQVRG---KLDHVKDTKAGVHT 59

  Fly    70 FLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKR 134
            |||:|:|.||....||:|..||.||.|:|.......:|.|.|..|..|          .|:.:|.
  Rat    60 FLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAMCLQNLDVINAE----------GLKEMKL 114

  Fly   135 LLPFLENQSEDCLYLNVFSPVNA--GANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVV 197
            .||.: :.||||||||:::|.:|  |:|   |||:|:|||........:.||||:|....::|||
  Rat   115 KLPPV-SMSEDCLYLNIYAPAHAHEGSN---LPVMVWIHGGGLMTGMASMYDGSLLTVNEDLVVV 175

  Fly   198 TLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACI 262
            |:.||||:|||.:....   ||| .|:|.:||:|||.|:||||..|||:|:.||:.|...|..|:
  Rat   176 TIQYRLGVLGFFSTGDE---HAR-GNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTCV 236

  Fly   263 NYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLR 327
            :..:.|| |.:||||.||:.||.|...:.:.:...:|:..:||...|...|.     |.:|.|||
  Rat   237 STHVVSP-MSQGLFHGAIMESGVALLPYLIADTSEMFSTMVAKVSGCEAMDS-----EALVHCLR 295

  Fly   328 DVPLEDLYLADIQAPNFLTSFGPS-VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQ---SSAG 388
             ...|    |:|.|.|.:....|: |||             :.:.|:.:...|...|:   |..|
  Rat   296 -AKSE----AEILAINKVVQMVPAVVDG-------------EFLPRHPKELLASEDFRPVPSIIG 342

  Fly   389 GGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFE 453
            ....:.|                                :.:...:.|.:.|...|..::|...:
  Rat   343 VNNDEYG--------------------------------WTIPLVMGTTQMIKELSRENLQAILK 375

  Fly   454 G---------ERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQ 509
            .         |..|.::..|:.:.      |...|:..::|:                 .:.|..
  Rat   376 KTTAQLMLPLECSDLLMEEYMGDI------EDPKTLQAQFTE-----------------LMEDFM 417

  Fly   510 FVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQ---TKDGDY 571
            ||.|.::......:::|                              .|||.|.:|   .|| ..
  Rat   418 FVIPALQVAHFQCSHAP------------------------------VYFYEFQHQITFLKD-IR 451

  Fly   572 PQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSL 636
            |..:...||:::|::||.    .|.....::|:.|..||..:|.:|.||||.||||....  |..
  Rat   452 PPHVKADHGDEIPFVFGY----FFWDMKTDFTEEEKLLSRRMMKYWANFARHGNPNSEGL--SYW 510

  Fly   637 PVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPE--LHRAGMEDVIAR 699
            ||.            ::|   |:||::..:|.:....:|.:|..|.:.:|:  ....|.:|
  Rat   511 PVM------------DHD---QQYLQLDTQPAVGRALKARRLQFWTKTLPQKIQELKGAQD---- 556

  Fly   700 HNLFRNHDDM 709
                 ||.::
  Rat   557 -----NHTEL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	181/656 (28%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	181/667 (27%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	49/109 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900