DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Bche

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	187/715 - (26%)
Similarity:	283/715 - (39%)	Gaps:	195/715 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVE 68
            :::..||.:||| .:|....|    :..|:         |:.|:.||:.||.:|:    ...:|.
  Rat     3 TEIHFLLWILLL-CMLFGKSH----TEEDV---------IITTKTGRVRGLSMPI----LGGTVT 49

  Fly    69 VFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRL----PNIQNETAALEKM--PKG 127
            .|||:|||.||....||...:....|..:..:.||:..|.|.:    |..|.     .:|  |.
  Rat    50 AFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQG-----SEMWNPN- 108

  Fly   128 RLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFE--WSSGNPYDGSVLAS 190
                        .|.|||||||||:.||   ...|...|:|:::|..|:  .||...|||..|..
  Rat   109 ------------TNLSEDCLYLNVWIPV---PKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTR 158

  Fly   191 YGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGH 255
            ...|:||::|||:|.||||....|..|   ..|.||.||..||.|||:||..|||:|.||||.|.
  Rat   159 VERVIVVSMNYRVGALGFLAFPGNSEA---PGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGE 220

  Fly   256 GTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWAL--VEDPVLFAIKLAKEVNCTIPDDINRH 318
            ..|||.::..:..|... .||.||||.|||:.:.||:  .|:.....:.|||.:.|:     ..:
  Rat   221 SAGAASVSLHLLCPQSY-PLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCS-----KEN 279

  Fly   319 HEQIVDCLRDVPLEDLYLAD--------IQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSR 375
            .::|:.|||....:::.|.:        |::.|    |||:|||..:      .|:...:.:..:
  Rat   280 EKEIITCLRSKDPQEILLNEKLVLPSDSIRSIN----FGPTVDGDFL------TDMPHTLLQLGK 334

  Fly   376 RSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESI 440
            ..:|                                                 .:|.||...|..
  Rat   335 VKTA-------------------------------------------------QILVGVNKDEGT 350

  Fly   441 WRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEI---------FYTIVNEYTDW--DRTSQHP 494
             .|..:... ||..:....|.|...:...|.:...:         ||     |.||  |:|   |
  Rat   351 -AFLVYGAP-GFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFY-----YVDWLGDQT---P 405

  Fly   495 INTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYF 559
            ...|:.....:.|...:.|                             |...:....:.....:|
  Rat   406 EVYREAFDDIIGDYNIICP-----------------------------ALEFTKKFAELEINAFF 441

  Fly   560 YVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTG 624
            |.|::::....:|:.||.:||.::.::||.||     ....|||::|...|.::|..|.|||:.|
  Rat   442 YYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPL-----ERRVNYTRAEEIFSRSIMKTWANFAKYG 501

  Fly   625 NPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGM-KPRIKNHFRAHQLSIWLRLIPEL 688
            :||              ..:..|..|..:....||||.:.. |.:|.:..||.|...|....|::
  Rat   502 HPN--------------GTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRLFFPKV 552

Fly 689 688
Rat 553 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	177/667 (27%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	179/687 (26%)
		Aes	<120..>272	CDD:223730	66/158 (42%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910