DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and NLGN2

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	841	Identity:	271/841 - (32%)
Similarity:	383/841 - (45%)	Gaps:	201/841 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.|||:.|:...|:: ..|..|..||||||||||....||.|..|||.|.|:|.:....|.|
Human    43 VVNTAYGRVRGVRRELNN-EILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPAC 106

  Fly   108 PQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEK---------- 162
            ||   |:.....|: .:|....:.|:....:::||||||||||::.|...|...|
Human   107 PQ---NLHGALPAI-MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPP 167

  Fly   163 --------KLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHA 219
                    |.||::|:||.|:...:||.:||||||:||.|:|.|||||||:||||:...    .|
Human   168 DTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGD----QA 228

  Fly   220 RVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSG 284
            ...||||:||:.||.|:.:||..|||||..:|:.|.|.||:|:|.|:.|... .|||.:||..||
Human   229 AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHS-EGLFQKAIAQSG 292

  Fly   285 SAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFG 349
            :|.|||::...|:.:...||.:|.|...|.     .:.|:|||..|..:|...|:|...:..:||
Human   293 TAISSWSVNYQPLKYTRLLAAKVGCDREDS-----AEAVECLRRKPSRELVDQDVQPARYHIAFG 352

  Fly   350 PSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYF 414
            |.|||.|:..     |.:.||.:                                       |.|
Human   353 PVVDGDVVPD-----DPEILMQQ---------------------------------------GEF 373

  Fly   415 GGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNYH----- 472
                   :|    ||:|.||..||.: :|  .:.:.::|......|..:..:|.|.|.|.
Human   374 -------LN----YDMLIGVNQGEGL-KFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDV 426

  Fly   473 LNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAG 536
            |.|   ||...|||| ||.:..  ..|.|.:|..:|.|:|||.|
Human   427 LRE---TIKFMYTDWADRDNGE--MRRKTLLALFTDHQWVAPAV--------------------- 465

  Fly   537 SPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQN 601
                 |.|...|....|   .|||.|.:..:....|:.....||::|||:||.|:|.....||.|
Human   466 -----ATAKLHADYQSP---VYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCN 522

  Fly   602 YTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK 666
            ::|::..||..||.:|||||:||:||:...||:.. :..:.|||..:.|..::...::||.||:|
Human   523 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF-IHTKPNRFEEVVWSKFNSKEKQYLHIGLK 586

  Fly   667 PRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASG 731
            ||:::::||::::.||.|:|.||....|       ||.....:..|.....|.|     .|||.|
Human   587 PRVRDNYRANKVAFWLELVPHLHNLHTE-------LFTTTTRLPPYATRWPPRP-----PAGAPG 639

  Fly   732 SSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFA 796
            :......:                               |:.|..            ....|..|
Human   640 TRRPPPPA-------------------------------TLPPEP------------EPEPGPRA 661

  Fly   797 PTTLANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVK 857
            .......|.|             |||.||||:|:|.|||.||:|.||.:||:||: |.|::
Human   662 YDRFPGDSRD-------------YSTELSVTVAVGASLLFLNILAFAALYYKRDR-RQELR 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	226/663 (34%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	226/663 (34%)
		Aes	<170..>268	CDD:223730	50/101 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668		11/92 (12%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698		12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870