Protein Alignment Nlg4 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 1019
• Identity: 311/1019 - (30%)
• Similarity: 450/1019 - (44%)
• Gaps: 265/1019 - (26%)

  Fly     1 MGESQLLLLLRLLLLPTV------LISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLD 59
            |...|.||.|.||..|..      ::.|:.........|...|:  :.:|.|.||::.||..||.
Human     1 MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQ--YPVVNTNYGKIRGLRTPLP 63

  Fly    60 SFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKM 124
            : ..|..||.:||||||:|||.:.||.|...|:.|.|||.:.:::.||||.|    :|.:.|..|
Human    64 N-EILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHL----DERSLLHDM 123

  Fly   125 -PKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEK----------------------KLPV 166
             |......|..|:.::::|:|||||||::.|...|||.|                      |.||
Human   124 LPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQNSKKPV 188

  Fly   167 IVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMA 231
            :|:|||.|:...:||..|||:|||||.|:|:|:||||||||||:...    .|...||||:||:.
Human   189 MVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGD----QAAKGNYGLLDQIQ 249

  Fly   232 ALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDP 296
            ||.||::|:..|||||..||:.|.|.||:|:: |:|......|||.:||:.||:|.||||:...|
Human   250 ALRWIEENVGAFGGDPKRVTIFGSGAGASCVS-LLTLSHYSEGLFQKAIIQSGTALSSWAVNYQP 313

  Fly   297 VLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGH 361
            ..:...||.:|.|.:.|..:     :|:|||:...::|....|....:..:|||.:||.||.
Human   314 AKYTRILADKVGCNMLDTTD-----MVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIP--- 370

  Fly   362 SNLDIDD---LMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMN 423
                 ||   ||.:                                       |.|       :|
Human   371 -----DDPQILMEQ---------------------------------------GEF-------LN 384

  Fly   424 MGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNY-----HLNEIFYTIV 481
                ||::.||..||.: :|  ...|.::|......|..:..:|.|.|.|     .|.|   ||.
Human   385 ----YDIMLGVNQGEGL-KFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRE---TIK 441

  Fly   482 NEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAAST 546
            ..|||| ...::|...|.|.||..:|.|:|||.|...|:.|           ..|||
Human   442 FMYTDW-ADKENPETRRKTLVALFTDHQWVAPAVATADLHA-----------QYGSP-------- 486

  Fly   547 SAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSE 611
                      .|||.|.:..:....|....:.||:::||:||.|::.....|..|::|::..||.
Human   487 ----------TYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSA 541

  Fly   612 AVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAH 676
            .||.:|||||:||:||:...||:.. :..:.|||..:.|..|:|..|.||.||:|||:::|:||.
Human   542 VVMTYWTNFAKTGDPNQPVPQDTKF-IHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRAT 605

  Fly   677 QLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSR 741
            :::.||.|:|.||               |.:::..|          :||
Human   606 KVAFWLELVPHLH---------------NLNEIFQY----------VST---------------- 629

  Fly   742 LLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLANA--- 803
                                       .|.|.|.:|  |..|.|...|.:  ...|||...|
Human   630 ---------------------------TTKVPPPDM--TSFPYGTRRSPA--KIWPTTKRPAITP 663

  Fly   804 ------SSDTLASGFEAAGYAA-----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVK 857
                  |.|...:|.|......     |||.||||||:|.|||.||:|.||.:||::||.|.|.
Human   664 ANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHET- 727

  Fly   858 TLQKQYQQRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVE----SHQDQAGQAAMLLQAA-- 916
                       |::    |.|.::....:.|.|:...:.:.::    .|:.::.||...|:..
Human   728 -----------HRR----PSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCP 777

  Fly   917 ---AAAAAAAANDVKPPPPHICSN-----TGMQQQQQVGGGSGG 952
               ......:.:|:....|:..:.     ||||........|||
Human   778 PDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGG 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	232/670 (35%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	232/675 (34%)