Protein Alignment Nlg4 and ces2a

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001070720.1
• Gene: ces2a / 566132
• ZFINID: ZDB-GENE-061013-99
• Length: 555
• Species: Danio rerio
• Alignment Length: 708
• Identity: 190/708 - (26%)
• Similarity: 272/708 - (38%)
• Gaps: 191/708 - (26%)

  Fly     6 LLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVF 70
            :||.|.|.|.|.    |.......:..:   |.|.|..|:.:|.:..|  .|       ..||.:
Zfish     5 VLLCLCLTLAPV----WSAPVQEDSGPV---AVLKHGSVRGQYVKAKG--SP-------AVVEQY 53

  Fly    71 LGVPYATPPTKQNRFSPTRAPAP---WDGIRISDKYSPVC---PQRLPNIQN----ETAALEKMP 125
            ||:|:|.||...:|.:   ||.|   |:|||.:.::..:|   |..||.|..    |..|:
Zfish    54 LGIPFAQPPVGPHRLA---APQPVQGWEGIRNATEHPLMCLQNPDILPAIAKAIDLEVTAI---- 111

  Fly   126 KGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNP-------- 182
                           ..|||||||||::| :..|..:||||:::|||...  :.|..
Zfish   112 ---------------GVSEDCLYLNVYTP-SQRAESEKLPVMIWIHGGGL--AMGGACMFKELCL 158

  Fly   183 YDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDP 247
            |||:.||:|.:||||.:.|||||||:.:....   ||: .|:|.:||:|||.|:||||:.|||||
Zfish   159 YDGTPLAAYEKVVVVVIQYRLGILGYFSTGDQ---HAK-GNWGFLDQIAALQWVQQNIEAFGGDP 219

  Fly   248 NSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIP 312
            .|||:||...|....:.|..|| |.:|||.|||..||.|......|:||...|..:|....|...
Zfish   220 QSVTIAGESAGGISASLLTLSP-MTKGLFQRAIFQSGVATVKGYFVKDPSTHAQVIANITECDFS 283

  Fly   313 DDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSF-GPSVDGVVIRPGHSNLDIDDLMARNSRR 376
            ..     |.:|.|:|::..|.:    |:|......| |.:|||..|:.....:           .
Zfish   284 SS-----EVLVKCIREMTEEQI----IKAAQKKGIFPGAAVDGEFIKAQPEEI-----------L 328

  Fly   377 SSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW 441
            .|.|  ||.                                          ..:|.|....|..|
Zfish   329 KSKD--FQK------------------------------------------VPILIGTTNHEFGW 349

  Fly   442 R----FSAHDIQNGFEGE-RRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTA 501
            .    |...:...|.:.: .:|::.......|..  .|.|   |.:||.   :.::.|...||..
Zfish   350 MLPQIFLPKEWVKGMDTKAAKDRLGLLNADGASG--ANGI---IADEYF---KNAKTPEEIRDAF 406

  Fly   502 VAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY-- 564
            ...|.|...|.|.:..           .|....||.|                  .|.|.|.:
Zfish   407 TELLGDIFMVIPSITV-----------ASYHREAGVP------------------VYMYEFQHGP 442

  Fly   565 QTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEH 629
            .|.:...|..:...|.:|:.::|||...|.........|:.|..|...||.:..||.|||:||.
Zfish   443 STANKFRPSFVKADHADDVGFVFGACFWDVHVKGLGTLTEEENQLCRTVMKYRANFIRTGSPNP- 506

  Fly   630 HRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPE 687
                            ..:.|..||. ..|||.:|::.......:..:|..:...:|:
Zfish   507 ----------------APVPWPVYDQ-SNKYLNLGLQQTEGQDLKKDKLLFFTEELPK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	179/663 (27%)
ces2a	NP_001070720.1	COesterase	25..541	CDD:395084	182/676 (27%)